高橋研究室

　　　　　　　　　　　　　　　　東北大学多元物質科学研究所

 

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全論文リスト

　　　　　　　　　　　　　　　　　　　　　　　　　＊主要論文リストはこちら　＊総説リストはこちら

　　　2008年　　

• Uzawa, T., Nishimura, C., Akiyama, S., Ishimori, K., Takahashi, S.*, Dyson, H. J., Wright, P. E.*
  "Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR” Proc. Natl. Acad. Sci. USA. 105, 13859-13864 (2008)
  
  
  
• Kimura,T., Maeda, A., Nishiguchi, S., Ishimori, K., Morishima, I., Konno, T., Goto, Y., Takahashi, S.* “Dehydration of mainchain amides in the final folding step of single chain monellin revealed by time-resolved infrared spectroscopy”
  Proc. Natl. Acad. Sci. USA. 105, 13391-13396 (2008)

　　　2007年　　

• Kinoshita, M. ,Kamagata, K., Maeda, A., Goto, Y., Komatsuzaki, T., Takahashi, S.* “Development of a technique for the investigation of folding dynamics of single proteins for extended time periods” Proc. Natl. Acad. Sci. USA, 104,10453-10458 (2007)
  
  
• Nishiguchi, S., Goto, Y., Takahashi, S.“Solvation and desolvation dynamics in apomyoglobin folding monitored by time-resolved infrared spectroscopy”
  J. Mol. Biol. 373,491-502 (2007)
  
  
• Matsumoto,S., Yane, A., Nakashima, S., Hashida, M., Fujita, M., Goto, Y., Takahashi, S.“A Rapid Flow Mixer with 11-ms Mixing Time Microfabricated by a Pulsed-laser Ablation Technique: Observation of a Barrier-limited Collapse in Cytochrome c Folding”
  J. Am. Chem. Soc. 129, 3840-3841 (2007)
  
  
• Lee,Y. H., Tamura, K., Maeda, M., Hoshino, M., Sakurai, K., Takahashi, S., Ikegami, T., Hase, T., Goto, Y.“Cores and pH-dependent Dynamics of Ferredoxin-NADP+ Reductase Revealed by Hydrogen / Deuterium Exchange”J. Biol. Chem. : 282,5959-5967 (2007)

　　　2006年　　

• Iwata, K., Fujiwara, T., Matsuki, Y., Akutsu, H., Takahashi, S., Naiki, H., Goto, Y. “3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR” Proc. Natl. Acad. Sci. USA, 103,18119-18124 (2006)
  
  
  
• Uzawa, T., Kimura, T., Ishimori, K., Morishima, I., Matsui, T., Ikeda-Saito, M., Takahashi, S., Akiyama, S., Fujisawa, T. “Time-resolved small-angle X-ray scattering investigation of the folding dynamics of heme oxygenase: Implication of the scaling relationship for the submillisecond intermediates of protein folding” J. Mol. Biol. : 357,997-1008 (2006)

　　　2005年　　

• Yamaguchi, K., Takahashi, S., Kawai, T., Naiki, H., Goto, Y. “Seeding-dependent propagation and maturation of amyloid fibril conformation” J. Mol. Biol. : 352, 952-960 (2005)
  
  
  
• Shintaku, M., Matsuura, K., Yoshioka, S., Takahashi, S., Ishimori, K., Morishima, I. “Absence of a detectable intermediate in the compound I formation of horseradish peroxidase at ambient temperature” J. Biol. Chem. :280, 40934-40938 (2005)
  
  
• Kameda, A., Hoshino, M., Higurashi, T., Takahashi, S., Naiki, H., Goto, Y.
  “Nuclear magnetic resonance characterization of the refolding intermediate of beta2-microglobulin trapped by non-native prolyl peptide bond” J. Mol. Biol. : 348, 383-397 (2005)
  
  
• Kimura, T., Akiyama, S., Uzawa, T., Ishimori, K., Morishima, I., Fujisawa, T., Takahashi, S.
  “Specifically collapsed intermediate in the early stage of the folding of ribonuclease A”
  J. Mol. Biol. : 350, 349-362 (2005)
  
  
• Wadai, H., Yamaguchi, K., Takahashi, S., Kanno, T., Kawai, T., Naiki, H., Goto Y.
  “Stereospecific amyloid-like fibril formation by a peptide fragment of beta2-microglobulin.”
  Biochemistry : 44, 157-164 (2005)
  
  
• Kimura, T., Uzawa, T., Ishimori, K., Morishima, I., Takahashi, S., Konno, T., Akiyama, S., Fujisawa, T. “Specific collapse followed by slow hydrogen-bond formation of beta-sheet in the folding of single-chain monellin.” Proc. Natl. Acad. Sci. USA. 102, 2748-2753 (2005)

　　　2004年　　

• Uzawa, T., Akiyama, S., Kimura, T., Takahashi, S.*, Ishimori, K., Morishima, I., Fujisawa, T.*
  "Collapse and search dynamics of apomyoglobin folding revealed by submillisecond observations of alpha-helical content and compactness." Proc. Natl. Acad. Sci. USA. 101, 1171-1176 (2004)
  
  
  
• Inuzuka, T., Yun, B. G., Ishikawa, H., Takahashi, S., Hori, H., Matts, R. L., Ishimori, K., Morishima, I. “Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.” J. Biol. Chem. 279, 6778-6682 (2004)
  
  
• Matsuura, K., Yoshioka, S., Takahashi S, Ishimori K, Mogi T, Hori H, Morishima I.
  “Dioxygen reduction by bo-type quinol oxidase from Escherichia coli studied by submillisecond-resolved freeze-quench EPR spectroscopy.” Biochemistry43, 2288-2296 (2004)
  
  
• Matsuura, K., Tosha, T., Yoshioka, S., Takahashi, S., Ishimori, K., Morishima, I.
  “Structuraland functional characterization of "laboratory evolved" cytochrome P450cam mutants showing enhanced naphthalene oxygenation activity.” Biochem. Biophys. Res. Commun. 323, 1209-1215 (2004)
  
  
• Ishikawa, H., Takahashi, S., Ishimori, K., Morishima, I. “Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin.” Biochem. Biophys. Res. Commun. 324, 1095-1100 (2004)
  
  
• Kumita, H., Matsuura, K., Hino, T., Takahashi, S., Hori, H., Fukumori, Y., Morishima, I., Shiro, Y.
  “NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle.”
  J. Biol. Chem. : 279,55247-55254 (2004)
  
  
• Ban, T., Hoshino, M., Takahashi, S., Hamada, D., Hasegawa, K., Naiki, H., Goto, Y. “Direct observation of Abeta amyloid fibril growth and inhibition.” J. Mol. Biol. : 344, 757-767 (2004)
  
  
• Egawa, T., Hishiki, T., Ichikawa, Y., Kanamori, Y., Shimada, H., Takahashi, S., Kitagawa, T., Ishimura, Y. “Refolding processes of cytochrome P450cam from ferric and ferrous acid forms to the native conformation. Formations of folding intermediates with non-native heme coordination state.” J. Biol. Chem. : 279, 32008-32017 (2004)

　　　2003年　　

• Tosha, T., Yoshioka, S., Takahashi, S., Ishimori, K., Shimada, H., Morishima, I. “NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes.”
  J. Biol. Chem. 278, 39809-39821 (2003)
  
  
• Egawa, T., Yoshioka, S., Takahashi, S., Hori, H., Nagano, S., Shimada, H., Ishimori, K., Morishima, I., Suematsu, M., Ishimura, Y. “Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.” J. Biol. Chem. 278, 41597-41606 (2003)
  
  
• Tanaka, M., Matsuura, K., Yoshioka, S., Takahashi, S., Ishimori, K., Hori, H., Morishima, I.
  “Activationof Hydrogen Peroxide in Horseradish Peroxidase Occurs within ~300μs Observed by a New Freeze-Quench Device” Biophys. J. (2003). 84, 1998-2004.

　　　2002年　　

• Akiyama, S., Takahashi, S., Kimura, T., Ishimori, K., Morishima, I., Nishikawa, Y.,Fujisama, T.,
  “Conformational Landscape of Cytochrome c Folding Studied by Microsecond-Resolved Small Angle X-ray Scattering” Proc. Natl. Acad. Sci. U. S. A.. 99. 1329-1334 (2002)
  
  
  
• Kimura, T., Takahashi, S., Akiyama, S., Uzawa, T., Ishimori, K., Morishima, I. “Direct Observation of the Multi-step Helix Formation of Poly-L-glutamic acids” J. Am. Chem. Soc. (2002). 124, 11596-11597.
  
  
• Yoshioka, S., Tosha, T., Takahashi, S., Ishimori, K., Morishima, I. “Roles of the Proximal Hydrogen Bonding Network in Cytochrome P450cam-Catalyzed Oxygenation”
  J. Am. Chem. Soc. 124, 14571-14579 (2002)
  
  
• Ishikawa, H., Yun, B.-G., Takahashi, S., Hori, H., Matts, R. L., Ishimori, K., Morishima, I. “NO-induced Activation Mechanism of the Heme-regulated eIF2 Kinase” J. Am. Chem. Soc. 124, 13696-13697 (2002)
  
  
• Tosha, T., Yoshioka, S., Takahashi, S., Hori, H., Ishimori, K., Morishima, I. “Molecular Mechanism of Electron Transfer Reaction in Cytochrome P450cam-Putidaredoxin: Roles of Gln360 at the Heme Proximal Site” Biochemistry 41, 13883-13893 (2002)

　　　2001年　　

• Ishikawa, H., Uchida, T., Takahashi, S., Ishimori, K., Morishima, I. “Ligand Migration in Human Myoglobin: Steric Effects of Isoleucine 107(G8) on O2 and CO Binding” Biophys. J. 80, 1507-1517 (2001)
  
  
  
• Shibata, Y., Ishikawa, H., Takahashi, S., Morishima, I. “Time-Resolved Hole-Burning Study on Myoglobin: Fluctuation of Restricted Water within Distal Pocket” Biophys. J. 80, 1013-1023 (2001)
  
  
• Yamamoto, K., Ishikawa, H., Takahashi, S., Ishimori, K., Morishima, I., Nakajima, H., Aono, S. “Binding of CO at the Pro2 Side Is Crucial for the Activation of CO-Sensing Transcriptional Activator CooA - H1-NMR Spectroscopic Studies” J. Biol. Chem. 276, 11473-11476 (2001)
  
  
• Yoshioka, S., Takahashi, S., Hori, H., Ishimori, K., Morishima, I. “Proximal Cysteine Residue Is Essential for the Enzymatic Activities of Cytochrome P450cam”
  Eur. J. Biochem. 268, 252-259 (2001)

　　　2000年　　

• Akiyama, S., Takahashi, S.,Ishimori, K., Morishima, I. “Stepwise Formation of Alpha-Helices During Cytochrome c Folding” Nat. Struct. Biol. 7, 514-520 (2000)
  
  
  
• Ihara, M., Shintaku, M., Takahashi, S., Ishimori, K., Morishima, I. “Conversion of an Electron-Transfer Protein into an Oxygen Binding Protein: The Axial Cytochrome b5 Mutant with an Unusually High O2 Affinity” J. Am. Chem. Soc. 122, 11535-11536 (2000)
  
  
• Ihara, M., Takahashi, S., Ishimori, K., Morishima, I. “Functions of Fluctuation in the Heme-Binding Loops of Cytochrome b5 Revealed in the Process of Heme Incorporation” Biochemistry 39, 5961-5970 (2000)
  
  
• Yoshioka, S., Takahashi, S., Ishimori, K., Morishima, I. “Roles of the Axial Push Effect in Cytochrome P450cam Studied with the Site-Directed Mutagenesis at the Heme Proximal Site” J. Inorg. Biochem. 81, 141-151 (2000)
  
  
• Han, S., Takahashi, S., Rousseau, D. L. “Time Dependence of the Catalytic Intermediates in Cytochrome c Oxidase” J. Biol. Chem. 275, 1910-1919 (2000)

　　　2000年以前　

• Sam, J. W., Takahashi, S., Lippai, I., Peisach, J., Rousseau, D. L. “Sequence-Specific Changes in the Metal Site of Ferric Bleomycin Induced by the Binding of DNA” J. Biol. Chem. 273, 16090-16097 (1998).
  
  
  
• Zamparelli, C., Verzili, D., Boffi, A., Chiancone, E., Takahashi, S., Rousseau, D. L., Regan, R., Gibson, Q. H. “The Unique Heme-Heme Interactions of the Homodimeric Scapharca Inaequivalvis Hemoglobin as Probed in the Protein Reconstituted with Unnatural 2,4 Heme Derivatives”
  Arch. Biochem. Biophys. 339, 275-282 (1997)
  
  
• Chan, C. K., Hu, Y., Takahashi, S., Rousseau, D. L., Eaton, W. A., Hofrichter, J. “Submillisecond Protein Folding Kinetics Studied by Ultrarapid Mixing” Proc. Natl. Acad. Sci. U. S. A. 94, 1779-1784 (1997)
  
  
• Boffi, A., Chiancone, E., Takahashi, S., Rousseau, D. L. “Stereochemistry of the Fe(II)- and Fe(III)-Cyanide Complexes of the Homodimeric Scapharca Inaequivalvis Hemoglobin. A Resonance Raman and FTIR Study” Biochemistry36, 4505-4509 (1997)
  
  
• Yeh, S. R., Takahashi, S., Fan, B. C., Rousseau, D. L. “Ligand Exchange During Cytochrome c Folding” Nat. Struct. Biol. 4, 51-56 (1997)
  
  
• Takahashi, S., Yeh, S. R., Das, T. K., Chan, C. K., Gottfried, D. S., Rousseau, D. L. “Folding of Cytochrome c Initiated by Submillisecond Mixing” Nat. Struct. Biol. 4, 44-50 (1997)
  
  
• Takahashi, S., Matera, K. M., Fujii, H., Zhou, H., Ishikawa, K., Yoshida, T., Ikedasaito, M., Rousseau, D. L. “Resonance Raman Spectroscopic Characterization of Alpha-Hydroxyheme and Verdoheme Complexes of Heme Oxygenase” Biochemistry36, 1402-1410 (1997)
  
  
• Matera, K. M., Takahashi, S., Fujii, H., Zhou, H., Ishikawa, K., Yoshimura, T., Rousseau, D. L., Yoshida, T., Ikedasaito, M. “Oxygen and One Reducing Equivalent Are Both Required for the Conversion of Alpha-Hydroxyhemin to Verdoheme in Heme Oxygenase” J. Biol. Chem. 271, 6618-6624 (1996)
  
  
• Wang, J. L., Takahashi, S., Hosler, J. P., Mitchell, D. M., Fergusonmiller, S., Gennis, R. B., Rousseau, D. L. “Two Conformations of the Catalytic Site in the aa3-Type Cytochrome c Oxidase from Rhodobacter Sphaeroides” Biochemistry34, 9819-9825 (1995)
  
  
• Wang, J. L., Takahashi, S., Rousseau, D. L. “Identification of the Overtone of the Fe-CO Stretching Mode in Heme-Proteins - a Probe of the Heme Active-Site” Proc. Natl. Acad. Sci. U. S. A. 92, 9402-9406 (1995)
  
  
• Wang, J. L., Rumbley, J., Ching, Y. C., Takahashi, S., Gennis, R. B., Rousseau, D. L. “Reaction of Cytochrome bo3 with Oxygen - Extra Redox Center(s) Are Present in the Protein” Biochemistry34, 15504-15511 (1995)
  
  
• Ishikawa, K., Takeuchi, N., Takahashi, S., Matera, K. M., Sato, M., Shibahara, S., Rousseau, D. L., Ikedasaito, M., Yoshida, T. “Heme Oxygenase-2 - Properties of the Heme Complex of the Purified Tryptic Fragment of Recombinant Human Heme Oxygenase-2” J. Biol. Chem. 270, 6345-6350 (1995)
  
  
• Takahashi, S., Ching, Y. C., Wang, J. L., Rousseau, D. L. “Microsecond Generation of Oxygen-Bound Cytochrome c Oxidase by Rapid Solution Mixing” J. Biol. Chem. 270, 8405-8407 (1995)
  
  
• Takahashi, S., Ishikawa, K., Takeuchi, N., Ikedasaito, M., Yoshida, T., Rousseau, D. L. “Oxygen-Bound Heme-Heme Oxygenase Complex - Evidence for a Highly Bent Structure of the Coordinated Oxygen” J.Am. Chem. Soc. 117, 6002-6006 (1995)
  
  
• Boffi, A., Takahashi, S., Spagnuolo, C., Rousseau, D. L., Chiancone, E. “Structural Characterization of Oxidized Dimeric Scapharca- Inaequivalvis Hemoglobin by Resonance Raman-Spectroscopy”J. Biol. Chem. 269, 20437-20440 (1994)
  
  
• Takahashi, S., Sam, J. W., Peisach, J., Rousseau, D. L. “Structural Characterization of Iron-Bleomycin by Resonance Raman-Spectroscopy” J. Am. Chem. Soc. 116, 4408-4413 (1994)
  
  
• Takahashi, S. , Wang, J. L., Rousseau, D. L., Ishikawa, K., Yoshida, T., Takeuchi, N., Ikedasaito, M.
  “Heme-Heme Oxygenase Complex - Structure and Properties of the Catalytic Site from Resonance Raman-Scattering” Biochemistry 33, 5531-5538 (1994)
  
  
• Takahashi, S. , Wang, J. L., Rousseau, D. L., Ishikawa, K., Yoshida, T., Host, J. R.,Ikedasaito, M.
  “Heme-Heme Oxygenase Complex Structure of the Catalytic Site and Its Implication for Oxygen Activation” J. Biol. Chem. 269, 1010-1014 (1994)
  
  
• Yumoto, I., Takahashi, S., Kitagawa, T., Fukumori, Y., Yamanaka, T. “The Molecular-Features and Catalytic Activity of CuA-Containing aco3-Type Cytochrome c Oxidase from a Facultative Alkalophilic Bacillus” J. Biochem. (Tokyo) 114, 88-95 (1993)
  
  
• Takahashi, S. , Ogura, T., Shinzawa-Itoh, K., Yoshikawa, S., Kitagawa, T. “Resonance Raman Studies on the CuA Site of Cytochrome c Oxidase Using a Multichannel Scanning Raman Spectrometer with a CCD Detector” Biochemistry 32, 3664-3670 (1993)
  
  
• Takahashi, S. , Ahn, J. S., Asaka, S., Kitagawa, T. “Multichannel Fourier-Transform Spectroscopy Using Two-Dimensional Detection of the Interferogram and Its Application to Raman- Spectroscopy” Appl. Spectrosc. 47, 863-868 (1993)
  
  
• Ogura, T., Takahashi, S., Hirota, S., Shinzawa-Itoh, K., Yoshikawa, S., Appelman, E. H., Kitagawa, T. “Time-Resolved Resonance Raman Elucidation of the Pathway for Dioxygen Reduction by Cytochrome-c-Oxidase” J. Am. Chem. Soc. 115, 8527-8536 (1993)

• Takahashi, S. , Ogura, T., Itoh-Shinzawa, K., Yoshikawa, S., Kitagawa, T.
  “Observation of the CuA-Ligand Stretching Resonance Raman Band for Cytochrome c Oxidase”
  J. Am. Chem. Soc. 113, 9400-9401 (1991)

• Ogura, T., Takahashi, S., Shinzawa-Itoh, K., Yoshikawa, S., Kitagawa, T. “Time-Resolved Resonance Raman Investigation of Cytochrome Oxidase Catalysis - Observation of a New Oxygen-Isotope Sensitive Raman Band” Bull. Chem. Soc. Jpn. 64, 2901-2907 (1991)
  
  
• Ogura, T., Takahashi, S., Shinzawa-Itoh, K., Yoshikawa, S., Kitagawa, T. “Observation of the Fe(II)-O2 Stretching Raman Band for Cytochrome Oxidase Compound A at Ambient-Temperature”
  J. Am. Chem. Soc. 112, 5630-5631 (1990)
  
  
• Ogura, T., Takahashi, S., Shinzawa-Itoh, K., Yoshikawa, S., Kitagawa, T. “Observation of the Fe4+=O Stretching Raman Band for Cytochrome Oxidase Compound B at Ambient-Temperature” J. Biol. Chem. 265, 14721-14723 (1990)
  
  
• Sakata, T., Takahashi, S., Terazima, M., Azumi, T. “Measurement of the Enhancement Factor of Chemically-Induced Dynamic Nuclear-Polarization in the Photolysis of Dibenzyl Ketone - Determination of the Spin Multiplicity of the Precursor” J. Phys. Chem. 95, 8671-8676 (1991)
  
  
• Terazima, M., Maeda, K., Sugawara, M., Takahashi, S., Azumi, T. “CIDEP and CIDNP Studies of the Hydrogen Abstraction of 9,10- Anthraquinone from Xanthene” J. Chem. Soc.-Faraday Trans. 86, 253-256 (1990)
  
  
• Takahashi, S., Terazima, M., Azumi, T. “Temperature-Dependence of the Enhancement Factor of CIDNP Created by the Photolysis of Benzoyl Peroxide” Chem. Phys. 142, 69-74 (1990)