At the Yonekura Laboratory, we employ state-of-the-art cryo-electron microscopy (cryo-EM) to elucidate the three-dimensional structures of a wide range of specimens with high precision. Our primary methodologies include single-particle analysis, electron 3D crystallography, and electron tomography.
These approaches enable us to investigate diverse biological samples such as photosynthetic complexes, membrane proteins, nucleic acid–binding proteins, and viruses, as well as non-biological materials including drug candidate molecules, organic semiconductors, and functional organic materials.
In addition to advancing measurement and analysis techniques—such as AI-driven data acquisition and processing—we integrate synchrotron radiation methods to uncover the structural mechanisms of complex molecular systems.
The Yonekura Laboratory conducts research using cryo-EM on both biological and material science samples, aiming not only at high-resolution structural analysis but also at applications relevant to industry.
Furthermore, we participate in a cooperative graduate program within the Graduate School of Life Sciences, and actively accept students from this program.