2024年
“Carrier-free nano-prodrugs for minimally invasive cancer therapy ”
K. Tanita, Y. Koseki, S. Kumar, F. Taemaitree, A. Mizutani, H. Nakatsuji, R. Suzuki, A. T. N. Dao, F. Fujishima, H. Tada, T. Ishida, K. Saijo, C. Ishioka, H. Kasai
Nanoscale, In press.
DOI: 10.1039/D4NR01763C
Press release “がん細胞内で効率的に薬物を放出する新規抗がん剤ナノ粒子の作製に成功”
“Anticancer Nano-prodrugs with Drug Release triggered by Intracellular Dissolution and Hydrogen Peroxide Response”
A. Shibata, Y. Koseki, K. Tanita, S. Kitajima, K. Oka, K. Maruoka, R. Suzuki, A. T. N. Dao, H. Kasai
Chem. Commun., 60, 6427–6430 (2024).
DOI: 10.1039/d4cc02252a
“Fabrication of carrier-free heterodimeric nano-prodrugs with podophyllotoxin and SN-38 for a co-delivery system”
Y. Koseki, K. Tanita, M. Nakamura, A. Shibata, K. Maruoka, T. Kamishima, H. Kasai
Mol. Cryst. Liq. Cryst., 768, 481–487 (2024).
DOI: 10.1080/15421406.2024.2353966
“Combined substituent number utilized machine learning for the development of antimicrobial agent”
K. Yamauchi, H. Nkatsuji, T. Kamishima, Y. Koseki, M. Kubo, H. Kasai
Sci. Rep., 14, 4106 (2024).
DOI: 10.1038/s41598-024-53888-2
Press release “機械学習で迅速に有効な新規抗菌薬候補分子を見つける新技術を開発”
2023年
“Sensitive and simple multi-ion detection using organic nanocrystal enrichment in paper analytical devices”
Grasianto, M. Fukuyama, M. Kasuya, DM Mott, Y. Koseki, H. Kasai, A. Hibara
Analytica Chimica Acta, 1273, 341451 (2023).
DOI: 10.1016/j.aca.2023.341451
“Total Synthesis of Azulene Derivative, a Blue Pigment Isolated from Lactarius indigo, and Colorant Application of Its Aqueous Dispersion”
K. Maruoka, R. Suzuki, T. Kamishima, Y. Koseki, A. T. N. Dao, T. Murafuji, H. Kasai
J. Agric. Food Chem., 71, 11607–11614 (2023).
DOI: 10.1021/acs.jafc.3c02387
“Label-Free Tracking of Nanoprodrug Cellular Uptake and Metabolism Using Raman and Autofluorescence Imaging”
M. Machida, T. Sugimura, S. Kajimoto, F. Taemaitree, Y. Koseki, H. Kasai, T. Nakabayashi
J. Phys. Chem. B, 127, 3851–3860 (2023).
DOI: 10.1021/acs.jpcb.3c01133
“Fabrication of anti-inflammatory nano eye-drops composed of dexamethasone prodrugs"
K. Tanita, M. Iijima, Y. Koseki, K. Sato, T. Nakazawa, H. Kasai
Mol. Cryst. Liq. Cryst., 762, 81–87 (2023).
DOI: 10.1080/15421406.2023.2180212
“Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy”
S. Thirumurugan, K. S. Muthiah, R. Sakthivel, M-Y Liao, H Kasai, R-J Chung
Pharmaceutics, 15, 822 (2023).
DOI: 10.3390/pharmaceutics15030822
2022年
“Ir‐Catalysed Cascade Reaction Promotes the Formation of Geometrically Selective Enones from Bis‐allyl Alcohols”
T. Kamishima, Y. Koseki, H. Nakatsuji, Sanjay Kumar, K. Tanita, H. Kasai
Eur. J. Org. Chem., 43, e202201002 (2022).
DOI: 10.1002/ejoc.202201002
“Development of camptothecin nano-prodrugs based on trimethyl lock groups toward selective drug release in cancer cells”
A. Shibata, Y. Koseki, K. Tanita, R. Suzuki, A. T. N. Dao, H. Kasai
Tetrahedron Lett., 103, 153989 (2022).
DOI: 10.1016/j.tetlet.2022.153989
“Versatile Conversions of Substituents in Guaiazulene: Synthesis of Carboxylic Acid Derivatives with Controlled Regiospecific Reactivities”
K. Maruoka, T. Kamishima, Y. Koseki, R. Suzuki, A. T. N. Dao, T. Murafuji, H. Kasai
Bull. Chem. Soc. Jpn., 95, 1169–1177 (2022).
DOI: 10.1246/bcsj.20220122
“Total synthesis and antimicrobial evaluation of (+)-hygrophorone B12 and its analogues”
T. Kamishima, M. Suzuki, K. Narita, Y. Koseki, T. Nonaka, H. Nakatsuji, H. Hattori, H. Kasai
Sci. Rep., 12, 7471 (2022).
DOI: 10.1038/s41598-022-11608-8
Press release “耐性菌に効果のある抗菌剤の簡便な合成方法を開発”
“Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery”
K. Maruoka, Y. Koseki, A. T. N. Dao, R. Suzuki, A. Batbayer, N. Sugeno, H. Umezawa, H. Kasai
Mol. Cryst. Liq. Cryst., 744, 100–108 (2022).
DOI: 10.1080/15421406.2022.2056384
“Polymeric functionalization of podophyllotoxin carrier-free drug nanoparticles for enhancing bioavailability and in vitro cellular imaging”
F. Taemaitree, M. Tamada, Y. Koseki, T. Onodera, H. Oikawa, H. Kasai
Mol. Cryst. Liq. Cryst., 743, 89–95 (2022).
DOI: 10.1080/15421406.2022.2052491
“Conversion of 2,5-Bis(hydroxymethyl)furan to Highly Oxidized Cyclopentenones under Catalyst-Free Condition in Water”
H. Nakatsuji, T. Kamishima, T. Nonaka, Y. Koseki, H. Kasai
Chem. Lett., 51, 497–499 (2022).
DOI: 10.1246/cl.220027
“Structural Correlations of the Nonlinear Optical Response in Polydiacetylene Nanotubes Hybridized with Gold Nanoparticles”
W. Ito-Washiyama, T. Onodera, M. Ageishi, R. Sato, B. Zhang, S. Kato, A. Masuhara, H. Kasai, H. Mamiya, H. Jinnai, Y. Takeda, H. Oikawa
J Phys Chem C, 126, 5, 2763–2771 (2022).
DOI: 10.1021/acs.jpcc.1c08884
“Effect of Molecular Distortion on the Optical Properties of Carotenoid-Based Nanoparticles”
R. Suzuki, K. Yasuhara, S. Deguchi
J. Phys. Chem. C, 126, 2607-2613 (2022).
DOI: 10.1021/acs.jpcc.1c08572
2021年
“Gold-Photodeposited Silver Nanowire Endoscopy for Cytosolic and Nuclear pH Sensingy”
Q. Zhang, T. Inose, M. Ricci, J. Li, Y. Tian, H. Wen, S. Toyouchi, E. Fron, Anh T. N. Dao, H. Kasai, S. Rocha, K. Hirai, B. Fortuni, H. Uji-i
ACS Appl. Nano Mater., 4,9 , 9886-9894 (2021).
DOI: 10.1021/acsanm.1c02
“Formation of multishell Au@Ag@Pt nanoparticles by coreduction method: a microscopic study”
Y. Takeuchi, H.-J. Lee, Anh T.N. Dao, H. Kasai, R. Teranishi, K. Kaneko
Mater. Today Chem., 21, 100515 (2021).
DOI: 10.1016/j.mtchem.2021.100515
“Fabrication of Size-controlled SN-38 Pure Drug Nanocrystals Through an Ultrasound-Assisted Reprecipitation Method toward Efficient Drug Delivery for Cancer Treatment”
Y. Koseki, Y. Ikuta, F. Taemaitree, N. Saito, R. Suzuki, Anh T.N. Dao, T. Onodera, H. Oikawa, H. Kasai
J. Cryst. Growth, 572, 126265 (2021).
DOI: 10.1016/j.jcrysgro.2021.126265
“Serum Albumin-Treated SN-38 Prodrug Nanoparticles toward Cancer Treatment”
F. Taemaitree, Y. Koseki, Anh T.N. Dao, H. Kasai
Chem. Lett., 50, 1555-1558 (2021).
DOI: 10.1246/cl.210253
“Organic nanocrystal enrichment in paper microfluidic analysis”
Grasianto, M. Fukuyama, DM Mott, Y. Koseki, H. Kasai, A. Hibara
Sens. Actuator B-Chem, 333, 129548 (2021).
DOI: 10.1016/j.snb.2021.129548
“Ultra-low dielectric properties of porous polyimide thin films reproduced by using the two kinds of templates with different particle sizes”
Y. Kourakata, T. Onodera, H. Kasai, H. Jinnai, H. Oikawa
Polymer, 212, 123115 (2021).
DOI: 10.1016/j.polymer.2020.123115
2020年
“FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery”
F. Taemaitree, B. Fortuni, Y. Koseki, E. Fron, S. Rocha, J. Hofkens, H. Uji-i, T. Inose, H . Kasai
Nanoscale, 12, 16710–16715 (2020).
DOI: 10.1039/d0nr04910g
Press release “効率的なナノ薬剤が薬効を示すまでの道のりを解明 ～細胞内でのナノ・プロドラッグを検出する方法の確立を通して～”
“Effect of the chemical structure on the drug release from brinzolamide based nano eye-drops”
Y. Koseki, Y. Ikuta, K. Sato, S. Aoyagi, S. Inada, T. Onodera, H. Oikawa, K. M Nishiguchi , T. Nakazawa, H. Kasai
Mol. Cryst. Liq. Cryst., 706, 122–128 (2020).
DOI: 10.1080/15421406.2020.1743447
“Self-assemble tannic acid and iron complexes on pure nanodrugs surface prevents aggregation and enhances anticancer drug delivery efficiency”
F. Taemaitree, Y. Koseki, N. Saito, R. Suzuki, Anh T.N. Dao, H. Kasai
Mol. Cryst. Liq. Cryst., 706, 116–121 (2020).
DOI: 10.1080/15421406.2020.1743446
“Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity”
K. Tanita, Y. Koseki, K. Shimizu, H. Umezawa, H. Kasai
Mol. Cryst. Liq. Cryst., 706, 79–85 (2020).
DOI: 10.1080/15421406.2020.1743441
“Solid-state polymerization behaviors of polydiacetylene nanofibers”
R. Chiba, T. Onodera, H. Kasai, H. Oikawa
Mol. Cryst. Liq. Cryst., 704, 89–96 (2020).
DOI: 10.1080/15421406.2020.1741807
“Low-Cytotoxic Gold-Coated Silver Nanoflowers for Intracellular pH Sensing”
Q. Zhang, H. Wen, K. Watanabe, I. Kotani, M. Ricci, B. Fortuni, Anh T.N. Dao, A. Masuhara, K. Hirai, H. Kasai, T. Inose, H. Uji-i
ACS Appl. Nano Mater., 3, 7643–7650 (2020).
DOI: 10.1021/acsanm.0c01278
“Chemical modification utilizing a terminal structure exposed on the specific surface of polymer-metal complex nanocrystal”
R. Suzuki, T. Onodera, H. Kasai, H. Oikawa
RSC Adv., 11, 6135–6138 (2020).
DOI: 10.1039/C9RA10244B
“Tropone Skeleton Enhances the Dispersion Stability of Nano-prodrugs”
K. Tanita, Y. Koseki, T. Kamishima, H. Kasai
Chem. Lett., 49, 222–224 (2020).
DOI: 10.1246/cl.190876
“抗がん治療のための新規DDS製剤ナノ・プロドラッグ”
小関 良卓、笠井 均
ナノ学会会報 The bulletin of the Society of Nano Science and Technology, 19(1), 15–20 (2020).
“ナノ・プロドラッグ：新たな抗がん薬輸送システムの細胞内挙動”
小関 良卓、F.Taemaitree、B. Fortuni、S.Rocha、雲林院 宏、猪瀬 朋子、笠井 均
月刊「細胞」, 52, 47–51 (2020).
2019年
“Nonlinear Optical Properties of Layered Type Hybridized Thin Films Consisted of Oriented Polydiacetylene Nanofibers and Silver Nanoparticles”
K. Wada, T. Onodera, H. Kasai, R. Sato, Y. Takeda, H. Oikawa
J. Phys. Chem., 123, 25781–25787 (2019).
DOI: 10.1021/acs.jpcc.9b05665
“Morphological effects on the third-order nonlinear optical response of polydiacetylene nanofibers”
H. Maki, R. Chiba, T. Onodera, H. Kasai, R. Sato, Y. Takeda, H. Oikawa
MRS Communications, 9, 1087-1092 (2019).
DOI: 10.1557/mrc.2019.97
“Formation of Five-membered Carbocycles from D-Glucose: A Concise Synthesis of 4-Hydroxy-2-(hydroxymethyl)cyclopentenone”
Y. Koseki, T. Watanabe, T. Kamishima, E. Kwon, H. Kasai
Bull. Chem. Soc. Jpn., 92, 1324–1328 (2019).
DOI: 10.1246/bcsj.20190063
“Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity”
Y. Koseki, Y. Ikuta, L. Cong, M. Takano, H. Tada, M. Watanabe, K. Gonda, T. Ishida, N. Ohuchi, K. Tanita, F. Taemaitree, Anh T.N. Dao, T. Onodera, H. Oikawa, H. Kasai
Bull. Chem. Soc. Jpn., 92, 1305–1313 (2019).
DOI: 10.1246/bcsj.20190088
“A facile synthesis of (+)/(−)-pentenomycin I and analogs, and their antimicrobial evaluation”
T. Kamishima, M. Suzuki, S. Aoyagi, T. Watanabe, Y. Koseki, H. Kasai
Tetrahedron Lett., 60, 1375–1378 (2019).
DOI: 10.1016/j.tetlet.2019.04.026
“Enhanced Fluorescence Emission and Magnetic Alignment Control of Biphasic Functionalized Composite Janus Particles”
N. Sakamoto, Y. Hirai, T. Onodera, T. Dezawa, Y. Shibata, H. Kasai, H. Oikawa, H. Yabu
Part. Part. Syst. Char., 1800311 (2019).
DOI:10.1002/ppsc.201800311
2018年
“One-Step Conversion to a Disubstituted Cyclopentenone from 2-Deoxy-D-Glucose and Application to Synthesis of Prostaglandin E1 Methyl Ester”
T. Kamishima, T. Nonaka, T. Watanabe, Y. Koseki, H. Kasai
Bull. Chem. Soc. Jpn., 91, 1691–1696 (2018). (Selected Paper)
DOI:10.1246/bcsj.20180241
Press release “バイオマス資源を原料とする炭素5員環化合物の創製および高付加価値の薬用化合物への応用”
“Nanocrystallization effect on luminescence properties of polymer-metal complex with different kinds of ligands”
R. Suzuki, T. Onodera, S. Deguchi, H. Kasai, H. Oikawa
J. Taiwan Inst. Chem. Eng., 1–5 (2018).
DOI: 10.1016/j.jtice.2018.02.022
“Attempt to visualize terminal structure on a specific facet in polymer–metal complex nanocrystals”
R. Suzuki, T. Onodera, H. Kasai, H. Oikawa
RSC Adv., 8, 16406–16409 (2018).
DOI: 10.1039/C8RA02165A-z
“緑内障治療薬ブリンゾラミド誘導体のナノ粒子作製と薬効評価”
小関 良卓, 笠井 均
化学工業, 69, 304–308 (2018).
“シクロペンテノン誘導体およびその製造方法”
笠井 均, 小関 良卓, 神島 尭明, 野中 利之
国際公開番号：WO/2018/109872, 2018年6月21日
2017年
“Synthesis of ordered carbonaceous frameworks from organic crystals”
H. Nishihara, T. Hirota, K. Matsuura, M. Ohwada, N. Hoshino, T. Akutagawa, T. Higuchi, H. Jinnai, Y. Koseki, H. Kasai, Y. Matsuo, J. Maruyama, Y. Hayasaka, H. Konaka, Y. Yamada, S. Yamaguchi, K. Kamiya, T. Kamimura, H. Nobukuni, F. Tani
Nat. Commun., 8, 109 (2017).
DOI: 10.1038/s41467-017-00152-z
“Creation of nano eye-drops and effective drug delivery to the interior of the eye”
Y. Ikuta, S. Aoyagi, Y. Tanaka, K. Sato, S. Inada, Y. Koseki, T. Onodera, H. Oikawa, H. Kasai
Sci. Rep., 7, 44229 (2017).
DOI: 10.1039/C8RA02165A-z
Press release “新規ナノ粒子点眼薬の開発と緑内障治療への応用”
“Fabrication of pseudo single crystalline thin films composed of polydiacetylene nanofibers and their optical properties”
Y. Iimori, T. Onodera, H. Kasai, M. Mitsuishi, T. Miyashita, H. Oikawa
Opt. Mater. Express, 7, 2218–2223 (2017).
DOI: 10.1364/OME.7.002218
“Fabrication of gold clusters photoreduced in gold-dendrimer complex nanoparticles”
A. Miura, T. Onodera, H. Kasai, T. Imaoka, K. Yamamoto, H. Oikawa
Opt. Mater. Express, 7, 2224–2229 (2017).
DOI: 10.1364/OME.7.002224
“Photoresponse of azopyridine-modified polymer-metal complex nanocrystals”
R. Suzuki, T. Onodera, H. Kasai, H. Oikawa
Mol. Cryst. Liq. Cryst., 109–114 (2017).
DOI: org/10.1080/15421406.2017.1355712
“新規ナノ薬剤 ナノ・プロドラッグ”
小関 良卓, 笠井 均
化学, 72, 68–69 (2017).
“ナノ・プロドラッグのin vivoにおける薬理効果”
小関 良卓, 幾田 良和, 笠井 均
技術情報協会, ＤＤＳ先端技術の製剤への応用開発, 第3章, 3節, 125–130 (2017).
ISBN978-4-86104-663-6
2016年
“Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of the Nano-prodrugs”
Y. Koseki, Y. Ikuta, T. Kamishima, T. Onodera, H. Oikawa, H. Kasai
Bull. Chem. Soc. Jpn. 89, 540–545 (2016).
DOI: 10.1246/bcsj.20150405
“Dispersion control of perylene fluorophores in a polystyrene microsphere”
K. Yoshioka, T. Onodera, H. Kasai, S. Okada, H. Oikawa
Mol. Cryst. Liq. Cryst. 629, 239–242 (2016).
DOI: 10.1080/15421406.2015.1096483
“Nanoscale deposition of metal-organic framework films on polymer nanosheets”
H. Ohara, S. Yamamoto, T. Onodera, H. Kasai, H. Oikawa, T. Miyashita, M. Mitsuishi
RSC Adv. 6, 74349–74353 (2016).
DOI: 10.1039/C6RA17997E
“Topical ocular dexamethasone decreases intraocular pressure and body weight in rats”
K. Sato, K. M. Nishiguchi, K. Maruyama, S. Moritoh, K. Fujita, Y. Ikuta, H. Kasai, T. Nakazawa
J. Negat. Results Biomed. 15:5 (2016).
DOI: 10.1186/s12952-016-0048-x
2015年
“Cytotoxicity of Pure Nanodrugs of SN-38 and Podophyllotoxin Dimers in Human Cancer HepG2, KPL-4, and MCF-7 Cells”
Y. Koseki, Y. Ikuta, T. Murakami, T. Onodera, H. Oikawa, L. Cong, H. Tada, K. Gonda, N. Ohuchi, H. Kasai
Mol. Cryst. Liq. Cryst. 622, 1–5 (2015).
DOI: 10.1080/15421406.2015.1096483
“Nanocrystallization of Insoluble Copper(I) Complex and Formation Mechanism”
R. Suzuki, T. Onodera, H. Kasai, H. Oikawa
Mol. Cryst. Liq. Cryst. 621, 150–155 (2015).
DOI: 10.1080/15421406.2015.1096450
“The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles”
Y. Ikuta, Y. Koseki, T. Onodera, H. Oikawa, H. Kasai
Chem. Commun. 51, 12835–12838 (2015).
DOI: 10.1039/C5CC04164C
“Novel development for fabrication of size- and morphology-controlled titanylphthalocyanine nanocrystals”
T. Kikuchi, K. Kogure, T. Onodera, H. Oikawa, H. Kasai
Chem. Lett. 44, 1232–1233 (2015).
DOI: 10.1246/cl.150365
“Organic crystal-binding peptides: Morphology control and one-pot formation of protein-displaying organic crystals”
T. Niide, K. Ozawa, H. Nakazawa, D. Oliveira, H. Kasai, M. Onodera, R. Asano, I. Kumagaia, M. Umetsu
Nanoscale 7, 20155–20163 (2015).
DOI: 10.1039/C5NR06471F
2014年
“Fabrication of fluorescent copper complex nanoparticles by the heterogeneous reaction process”
R. Suzuki, T. Onodera, H. Kasai, H. Oikawa
Jpn. J. Appl. Phys. 53, 06JH03 (2014).
DOI: 10.7567/JJAP.53.06JH03
2013年
“Thermal-induced shape transformation of solvated C60 microcrystals”
Z. Tan, A. Masuhara, H. Kasai, H. Nakanishi, H. Oikawa
Carbon 64, 370–376 (2013).
DOI: 10.1016/j.carbon.2013.07.087
“Facile deposition of gold nanoparticles on C60 microcrystals with unique shapes”
Z. Tan, A. Masuhara, S. Ohara, H. Kasai, H. Nakanishi, H. Oikawa
J. Nanopart. Res 15:2029 (2013).
DOI: 10.1007/s11051-013-2029-z
“Fabrication of pure nanodrugs of podophyllotoxin dimer and their anticancer activity”
Y. Ikuta, Y. Koseki, T. Murakami, M. Ueda, H. Oikawa, H. Kasai
Chem. Lett. 42, 900–901 (2013).
DOI: 10.1246/cl.130224
“Diarylethene nanorods: Preparation, crystal structure, and photochromic properties”
N. Tagawa, A. Masuhara, S. Okada, H. Katagiri, T. Onodera, H. Kasai, H. Oikawa
Chem. Lett. 42, 636–637 (2013).
DOI: 10.1246/cl.130023
“Highly controlled plasmonic emission enhancement from metal-semiconductor quantum dot complex nanostructures”
H. Naiki, A. Masuhara, S. Masuo, T. Onodera, H. Kasai, H. Oikawa
J. Phys. Chem. C 117, 2455–2459 (2013).
DOI: 10.1021/jp305408p
2012年
“Perylene and perylene-derivative nano-cocrystals: Preparation and physicochemical property”
K. Baba, S. Konta, D. Oliveira, K. Sugai, T. Onodera, A. Masuhara, H. Kasai, H. Oikawa, H. Nakanishi
Jpn. J. Appl. Phys. 51, 125201 (2012).
DOI: 10.1143/JJAP.51.125201
“Fabrication of doped Cu-TCNQ nanocrystals and their optoelectronic properties”
T. Onodera, S. Matsuo, K. Hiraishi, A. Masuhara, H. Kasai, H. Oikawa
CrystEngComm 14, 7586–7589 (2012).
DOI: 10.1039/C2CE25926E
“Cyclic transformation in shape and crystal structure of C 60 microcrystals”
A. Masuhara, Z. Tan, M. Ikeshima, T. Sato, H. Kasai, H. Oikawa, H. Nakanishi
CrystEngComm 14, 7787–7791 (2012).
DOI: 10.1039/C2CE25798J
“Relationship between the surface morphology and optical property of organic nanocrystals”
E. Kwo, H-R Chung, H. Kasai, H. Oikawa, H. Nakanishi
Mol. Cryst. Liq. Cryst. 566, 147–150 (2012).
DOI: 10.1080/15421406.2012.701877
“Creation of pure nanodrugs and their anticancer properties”
H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
Angew. Chem. Int. Ed. 51 , 10315–10318 (2012).
DOI: 10.1002 / anie.201204596