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## De novo Protein Design: From Computation to Biomedical Applications

Proteins are the molecular machines of life, refined through evolution to perform diverse functions. De novo protein design—the computational creation of novel proteins—emerged in the 1980s and has recently accelerated with advances in AI and computational methods, attracting growing interest for medical and industrial applications.

Led by Distinguished Professor William DeGrado, a pioneer in this field, our laboratory at IMRAM integrates computational design with experimental validation to advance de novo protein research. Our work focuses on membrane proteins, artificial enzymes, and functional nanostructures, with applications in cell manipulation and drug discovery. Leveraging IMRAM’s interdisciplinary environment, we aim to establish an international hub for de novo protein design.

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Research Keywords
– De novo protein
– Computational design
– Membrane proteins
– Drug delivery