΄_Ά(2005NΘ~ͺ)
2023N
Formation
of Direction-Controllable Pseudorotaxane and Catenane Using Chemically
Cyclized Oligodeoxynucleotides and Their Noncovalent RNA Labeling
Kazuki Kuwahara, Sayaka Yajima, Yuuhei Yamano, Fumi Nagatsugi*, Kazumitsu Onizuka*, Bioconjugate Chem. 2023, 34, .
(Supplementary Jounal Cover)
Synthesis of
6-Alkynylated Purine-Containing DNA via On-Column Sonogashira Coupling
and Investigation of Their Base-Pairing Properties
Hidenori Okamura*, Giang Hoang Trinh, Zhuoxin Dong, Wenjue Fan, Fumi Nagatsugi*, Molecules 2023, 28, 1766.
o-Nitrobenzyl Oxime Ethers Enable Photoinduced Cyclization Reaction to Provide Phenanthridines under Aqueous Conditions
Hidenori Okamura*, Momoka Iida, Yui Kaneyama, Fumi Nagatsugi*, Org. Lett. 2023, 25, 466470.
(Supplementary Journal Cover)
  @ 
2022N
Reactivity Modulation of Reactive OFF-ON Type G-Quadruplex Alkylating Agents
Yutong Chen#, Kazumitsu Onizuka#, Madoka E. Hazemi, Fumi Nagatsugi*, Bioconjugate Chem. 2022, 33, 2097-2102.
Photochemical labeling of nucleic acid by photocatalyst tethered DNA probe
Yuuhei Yamano, Kazumitsu Onizuka*, Madoka Sasaki, Shinichi Sato, Fumi Nagatsugi*, Chem. Lett. 2022, 51, 1121-1124.
Selective chemical modification to the higher-order structures of nucleic
acids
Fumi Nagatsugi*, Kazumitsu Onizuka, Chem. Rec. 2022, e202200194.
Hybridization-specific chemical reactions to create interstrand crosslinking
and threaded structures of nucleic acids
Kazumitsu Onizuka*, Yuuhei Yamano, Ahmed Mostafa Abdelhady, Fumi Nagatsugi*, Org. Biomol. Chem. 2022, 20, 4699-4708.
Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface
Hidenori Okamura*, Giang Hoang Trinh, Zhuoxin Dong, Yoshiaki Masaki, Kohji Seio, Fumi Nagatsugi*, Nucleic Acids Res. 2022, 50, 3042-3055.
Synthesis of Crosslinked 2f-OMe RNA Duplexes using 2-Amino-6-Vinylpurine
and Their Application for Effective Inhibition of miRNA Function
Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura, Yasuo Komatsu, Fumi Nagatsugi*, Current Protocols 2022, 2, e386.
Rapid alkene-alkene photo-cross-linking on the base flipping-out field
in duplex DNA
Ahmed Mostafa Abdelhady, Kazumitsu Onizuka*, Kei Ishida, Sayaka Yajima,
Eriko Mano, Fumi Nagatsugi*, J. Org. Chem. 2022, 87,.
(Supplementary Journal Cover)
   
 
2021N
Synthesis of Crosslinked 2f-OMe RNA Duplexes and Their Application for Effective Inhibition of miRNA Function
Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura,
Yasuo Komatsu, Fumi Nagatsugi*, Bioorg. Med. Chem. Lett. 2021, 48, 128257.
Selective alkylation of parallel G-quadruplex structure
Kazumitsu Onizuka, Erchissaran Ganbold, Yue Ma, Shogo Sasaki, Madoka E.
Hazemi, Yutong Chen, Norihiro Sato, Mamiko Ozawa, Kazuo Nagasawa*, Fumi Nagatsugi*, Org. Biomol. Chem. 2021, 19, 2891-2894.
(Inside front cover)
2020N
Design of the Crosslinking Reactions for Nucleic Acids-Binding Protein
and Evaluation of the Reactivity
Kenta Odaira, Ken Yamada, Shogo Ishiyama, Hidenori Okamura and Fumi Nagatsugi*, Appl. Sci. 2020, 10, 7709.
Functional G-quadruplex binding molecules
Fumi Nagatsugi*, Kazumitsu Onizuka, Chem. Lett. 2020, 49, 771-780.
(cover picture, inside cover)
2019N
Reactive OFF-ON type alkylating agents for higher-ordered structures of
nucleic acids
Kazumitsu Onizuka#, Madoka E. Hazemi#, Norihiro Sato, Gen-ichiro Tsuji, Shunya Ishikawa, Mamiko Ozawa, Kousuke
Tanno, Ken Yamada, Fumi Nagatsugi*, Nucleic Acids Res. 2019, 47, 6578-6589.
(#Joint first authors)
Alkyne-alkyne photo-crosslinking on the flipping-out field
Kazumitsu Onizuka*, Kei Ishida, Eriko Mano, Fumi Nagatsugi*, Org. Lett. 2019, 21, 2833-2837.
Development of the binding molecules for the RNA higher-order structures
based on the guanine-recognition by the G-clamp
Hirotaka Murase, Fumi Nagatsugi*, Bioorg. Med. Chem. Lett. 2019, 29, 1320-1324.
Synthesis of RNA cross-linking oligonucleotides modified with 2-amino-7-deaza-7-propynyl-6-vinylpurine
Ken Yamada, Yusuke Abe, Fumi Nagatsugi*, Current Protocols in Nucleic Acid Chemistry 2019, e79.
2018N
Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation
Kazumitsu Onizuka*, Takuya Miyashita, Tomoko Chikuni, Mamiko Ozawa, Hiroshi
Abe, Fumi Nagatsugi*, Nucleic Acids Res. 2018, 46, 8710-8719.
Synthesis and properties of 2'-OMe-RNAs modified with cross-linkable 7-deazaguanosine derivatives
Ken Yamada, Yusuke Abe, Hirotaka Murase, Yuta Ida, Shinya Hagihara, Fumi Nagatsugi*, J. Org. Chem. 2018, 83, 8851-8862.
Vinyldiaminotriazine-acridine conjugate as G-quadruplex alkylating agent
Madoka E. Hazemi, Kazumitsu Onizuka, Tomohito Kobayashi, Akira Usami, Norihiro Sato, Fumi Nagatsugi*, Bioorg. Med. Chem., 2018, 26, 3551-3558.
Alkylating probes for G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex
Norihiro Sato, Shuntaro Takahashi, Hisae Tateishi-Karimata, Madoka E. Hazemi,
Tomoko Chikuni, Kazumitsu Onizuka, Naoki Sugimoto, Fumi Nagatsugi*, Org. Biomol. Chem. 2018, 16, 1436-1441.
Selective alkylation of T-T mismatched DNA using vinyldiaminotriazine-acridine
conjugate
Kazumitsu Onizuka, Akira Usami, Yudai Yamaoki, Tomohito Kobayashi, Madoka
E. Hazemi, Tomoko Chikuni, Norihiro Sato, Kaname Sasaki, Masato Katahira,
Fumi Nagatsugi*, Nucleic Acids Res.2018, 46, 1059-1068.
2017N
Pseudorotaxane formation via the slippage process with chemically-cyclized
oligonucleotides
Kazumitsu Onizuka*, Tomoko Chikuni, Takuya Amemiya, Takuya Miyashita, Kyoko
Onizuka, Hiroshi Abe, Fumi Nagatsugi*, Nucleic Acids Res., 2017, 45, 5036-5047.
Synthesis of native-like crosslinked duplex RNA and study of its properties
Kazumitsu Onizuka, Madoka E. Hazemi, Justin M. Thomas, Leanna R. Monteleone,
Ken Yamada, Shuhei Imoto, Peter Beal, Fumi Nagatsugi*, Bioorg. Med. Chem., 2017, 25, 2191-2199.
Synthesis and properties of cross-linkable DNA duplex using 4-amino-2-oxo-6-vinyl-1,3,5-triazine
Ken Yamada, Shogo Ishiyama, Kazumitsu Onizuka, Fumi Nagatsugi*, Tetrahedron, 2017, 73, 1424-1435.
selected as a cover picture
2016N
Synthesis of peptide nucleic acids (PNA) with a crosslinking agent to RNA and effective inhibition of dicer
Takuya Akisawa, Ken Yamada, Fumi Nagatsugi*, Bioorg. Med. Chem. Lett., 2016,
26, 5902-5906.
2015N
A new strategy for site-specific alkylation of DNA using oligonucleotides
containing an abasic site and alkylating probes
Norihiro Sato, Genichiro Tsuji, Yoshihiro Sasaki, Akira Usami, Takuma Moki, Kazumitsu Onizuka, Ken Yamada, Fumi Nagatsugi*, Chem. Commun., 2015, 51, 14885-14888.
Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine
derivatives and structural analysis of the adducts
Shuhei Kusano, Shogo Ishiyama, Sik Lok Lam*, Tsukasa Mashima, Masato Katahira,
Kengo Miyamoto, Misako Aida, Fumi Nagatsugi*, Nucleic Acids Res., 2015, 43, 7717-7730.
Stabilization of the i-motif structure by the intra-strand cross-link formation
Kenji Kikuta, Haishun Piao, John Brazier, Yosuke Taniguchi, Kazumitsu Onizuka,
Fumi Nagatsugi, Shigeki Sasaki*
Bioorg.
Med. Chem. Lett., 2015,
25, 3307-3310.
Synthesis of Peptide nucleic acids containing a crosslinking agent and evaluation of their reactivities
Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi*
Molecules, 20(3), 4708-4719 (2015)
2014N
Automatic pseudorotaxane formation targeting on nucleic acids using a pair
of reactive oligodeoxynucleotides
Kazumitsu Onizuka*, Fumi Nagatsugi, Yoshihiro Ito, Hiroshi Abe*
J. Am. Chem. Soc., 136(20), 7201-7204, (2014)
Development of the crosslinking reactions to RNA triggered by oxidation
Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Shinya Hagihara, Fumi Nagatsugi*
Chem. Commun., 50(30), 3951-3954, (2014)
2013N
The Crosslink formation of 2'-OMe oligonucleotide containing 2-amino-6-vinylpurine protects mRNA from miRNA-mediated silencing
Shinya Hagihara, Wei-Chen Lin, Shuhei Kusano, Xiao-guang Chao, Tsuneaki
Hori, Shuhei Imoto, Fumi Nagatsugi
ChemBioChem, 14(12), 1427-1429, (2013)
selected as cover picture
4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective
formation of interstrand cross-links with RNA and duplex DNA
Atsushi Nishimoto, Daichi Jitsuzaki, Kazumitsu Onizuka, Yosuke Taniguchi,
Fumi Nagatsugi, Shigeki Sasaki
Nucleic Acids Res., 41(13), 6774-6781, (2013)
Synthesis of peptide-conjugated light-driven molecular motors and evaluation
of their DNA-binding properties
Fumi Nagatsugi, Yusuke Takahashi, Maiko Kobayashi, Shunsuke Kuwahara, Shuhei Kusano,
Tomoko Chikuni, Shinya Hagihara, Nobuyuki Harada
Mol Biosyst., 9(5), 969-973, (2013)
2012N
Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation
of the reactivity
Shuhei Kusano, Tomoya Sakuraba, Shinya Hagihara, Fumi Nagatsugi
Bioorganic & Medical Chemistry Letters, 22(22), 6957-6961, (2012)
Production of turncated protein by the crosslink formation of mRNA with
2'-OMe oligoribonucleotide containig 2-amino-6-vinylpurine
Shinya Hagihara, Shuhei Kusano, Wei-Chen Lin, Chao-Xiao Guang, Tsuneaki Hori, Shuhei Imoto, Fumi Nagatsugi
Bioorganic & Medical Chemistry Letters, 22(12), 3870-3872, (2012)
Fast DNA Interstrand Cross-Linking Reaction by 6-Vinylpurine
Shuhei Imoto, Tomoko Chikuni, Hisao Kansui, Takehisa Kunieda, Fumi Nagatsugi
Nucleosides, Nucleotides & Nucleic Acids, 31(10), 752-762, (2012)
2011N
Dependency of the cross-linking reactivity with 2-amino-6-vinylpurine on
the neighboring bases
Fumi Nagatsugi, Shinya Hagihara, Shuhei Kusano, Chao-Xiao Guang
Nucleic Acid Therapeutics, 21(5), A37, (2011)
Development of the Highly Selective Reactions to Target Gene for the Control
of the Gene Expression in Cells
Fumi Nagatsugi
Journal of Synthetic Organic Chemistry Japan, 69(2), 108-117, (2011)
Induced cross-linking reactions to target genes using modified oligonucleotides
Fumi Nagatsugi, Shuhei Imoto
Organic & Biomolecular Chemistry, 9(8), 2579-2585, (2011)
Alternation of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine
and evaluation of antisense effects
Shuhei Imoto, Tsuneaki Hori, Shinya Hagihara, Yosuke Taniguchi, Shigeki
Sasaki, Fumi Nagatsugi
Bioorganic & Medicinal Chemistry Letters, 20(20), 6121-6124, (2011)
Synthesis of Reactive Oligonucleotides for Gene Targeting and Their Application
to Gene Expression Regulation
Fumi Nagatsugi, Shigeki Sasaki
Bulletin of the Chemical Society of Japan, 83(7), 744-755, (2011)
2010N
The alkyl-connected 2-amino-6-vinylpurine (AVP) crosslinking agent for
improved selectivity to the cytosine base in RNA
Yosuke Taniguchi, Yusuke Kurose, Takamasa Nishioka, Fumi Nagatsugi, Shigeki Sasaki
Bioorg. Med. Chem., 18, 2894-2901, (2010)
2009N
Highly Selective and Efficient Interstrand Cross-Linking Formation to Thymine
Without Photo-Irradiation
Keiichi Hattori, Tomoya Hirohama, Shuhei Imoto, Shuhei Kusano, Fumi Nagatsugi
Chem. Comm. 42, 6463-6465, (2009)
Incorporation of an Inducible Nucleotide Analog into DNA by DNA Polymerases
Md. Monsur Ali, Shuhei Imoto, Shigeki Sasaki, Yingfu Li, Fumi Nagatsugi
Bioorg. Med. Chem., 17, 2859-2863, (2009)
2008N
Synthesis and evaluation of the luciferase-oligodeoxynucleotide for the sequence-selective detection of nucleic acids.
Fumi Nagatsugi, Ryusuke Nakahara, Kaori Inoue, Shigeki Sasaki
Arch Pharm, 9, 341, 562-7 (2008)
DNA Templated Click Chemistry for Creation of Novel DNA Binding Molecules
Shuhei Imoto, Tomoya Hirohama, Fumi Nagatsugi
Bioorg. Med. Chem. Lett., 18, 5660-5663, (2008)
2007N
Efficient Synthesis of 6-Substituted Purine Derivatives using Pd-Catalyzed
Cross-Coupling Reactions with 2'-Deoxyguanosine O6-Tosylate
Fumi Nagatsugi, Yuki Ogata, Shuhei Imoto, Shigeki Sasaki
Heterocycles, 73, 493-501 (2007)
Development Of The Novel Drug Releasing System Triggered By Hybridization With Target Sequence
Fumi Nagatsugi, Shizuka Nakayama, Shigeki Sasaki
Nucleosides, Nucleotides & Nucleic Acids, 26, 799-803 (2007)
2006N
Intracellular Ability of an Inducible Alkylation System to Exhibit Antisense
Effects with Greater Potency and Selectivity
Md. Monsur Ali, Motoi Oishi, Fumi Nagatsugi, Kenji Mori, Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki
Angew. Chem. Int. Ed., 45, 3136-3140 (2006)
Application of unnatural
oligonucleotides to chemical modification of gene expression
Shigeki Sasaki, Fumi Nagatsugi
Current Opin. Chem. Biol., 10,
615-621 (2006)
Application of 2-Amino-6-Vinylpurine
as an Efficient Agent for Conjugation of Oligonucleotides
Md. Monsur Ali, Fumi Nagatsugi, Shigeki Sasaki, Ryusuke Nakahara, Minoru Maeda
Nucleosides, Nucleotides, and Nucleic Acids, 25,
159-169 (2006)
Effects of Halogenated WNA Derivatives
on Sequence Dependency for Expansion of Recognition Sequences in the Non-Natural
Type Triplexes
Yosuke Taniguchi, Ayako Nakamura, Yusuke Senko, Fumi Nagatsugi, Shigeki Sasaki
J. Org. Chem., 71,
2115-2122 (2006)
2005N
Development of
efficient packaging method of oligodeoxynucleotides by a condensed nano
particle in lipid envelope structure
Yuma Yamada, Kentaro Kogure, Yoshio. Nakamura, Kaori Inoue, Hidetaka Akita,
Fumi Nagatsugi, Shigeki Sasaki, Tetsuya Suhara, Hideyoshi Harashima
Biological & Pharmaceutical Bulletin,28,1939-1942 (2005)
Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide:
Polylon complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide
conjugate
Motoi Oishi, Tetsuya Hayama, Yoshitsugu Akiyama, Seiji Takae, Atsushi Harada, Yuichi Yamasaki, Fumi Nagatsugi, Shigeki Sasaki, Yukio Nagasaki, Kazunori Kataoka
Biomacromolecules,6,2449-2454(2005)
Smart Polyion Complex Micelles for Targeted
Intracellular Delivery of PEGylated Antisense Oligonucleotide with
Acid-Labile Linkage
Motoi Oishi, Fumi Nagatsugi, Shigeki Sasaki, Yukio Nagasaki, Kazunori Kataoka
ChemBioChem,6,718-725 (2005)
Hybridization-Promoted
and Cytidine-Selective Activation for Cross-Linking with the Use of
2-Amino-6-Vinylpurine Derivatives
Takeshi Kawasaki, Fumi Nagatsugi, Md. Monsur Ali, Minoru Maeda, Kumiko Sugiyama, Kenji Hori, Shigeki Sasaki
J. Org. Chem.,70,14-23 (2005)
Design of highly
efficient and selective transfer reaction of nitrosyl group to dC and
dmC resulting in specific deamination
Md. Monsur Ali, Fumi Nagatsugi, Shizuka Nakayama, Md. Rowshon Alam, Takeshi Kawasaki, Shigeki Sasaki
Nucleosides, Nucleotides and Nucleic Acids,24,721-724(2005)
Expansion of triplex recognition codes
by the use of novel bicyclic nucleoside derivatives (WNAj
Yosuke Taniguchi, Ayako Nakamura, Yusuke Senko, Keiichi Kodama, Fumi Nagatsugi, Shigeki Sasaki
Nucleosides, Nucleotides and Nucleic Acids,24,823-827(2005)
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