2000年～2010年

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2008年　

  • Uzawa, T., Nishimura, C., Akiyama, S., Ishimori, K., Takahashi, S.*, Dyson, H. J., Wright, P. E.*
    “Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR” Proc. Natl. Acad. Sci. USA. 105, 13859-13864 (2008) [Abstract]
  • Kimura,T., Maeda, A., Nishiguchi, S., Ishimori, K., Morishima, I., Konno, T., Goto, Y., Takahashi, S.* “Dehydration of mainchain amides in the final folding step of single chain monellin revealed by time-resolved infrared spectroscopy”
    Proc. Natl. Acad. Sci. USA. 105, 13391-13396 (2008)[Abstract]

2007年　

  • Kinoshita, M. ,Kamagata, K., Maeda, A., Goto, Y., Komatsuzaki, T., Takahashi, S.* “Development of a technique for the investigation of folding dynamics of single proteins for extended time periods” Proc. Natl. Acad. Sci. USA, 104,10453-10458 (2007）[Abstract]
  • Nishiguchi, S., Goto, Y., Takahashi, S.“Solvation and desolvation dynamics in apomyoglobin folding monitored by time-resolved infrared spectroscopy”
    J. Mol. Biol. 373,491-502 (2007) [Abstract]
  • Matsumoto,S., Yane, A., Nakashima, S., Hashida, M., Fujita, M., Goto, Y., Takahashi, S.“A Rapid Flow Mixer with 11-ms Mixing Time Microfabricated by a Pulsed-laser Ablation Technique: Observation of a Barrier-limited Collapse in Cytochrome c Folding”
    J. Am. Chem. Soc. 129, 3840-3841 (2007) [Abstract]
  • Lee,Y. H., Tamura, K., Maeda, M., Hoshino, M., Sakurai, K.,Takahashi, S., Ikegami, T., Hase, T., Goto, Y.“Cores and pH-dependent Dynamics of Ferredoxin-NADP+ Reductase Revealed by Hydrogen / Deuterium Exchange”J. Biol. Chem. : 282,5959-5967 (2007) [Abstract]

2006年　

  • Iwata, K., Fujiwara, T., Matsuki, Y., Akutsu, H., Takahashi, S., Naiki, H., Goto, Y. “3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR” Proc. Natl. Acad. Sci. USA, 103,18119-18124 (2006) [Abstract]
  • Uzawa, T., Kimura, T., Ishimori, K., Morishima, I., Matsui, T., Ikeda-Saito, M., Takahashi, S., Akiyama, S., Fujisawa, T. “Time-resolved small-angle X-ray scattering investigation of the folding dynamics of heme oxygenase: Implication of the scaling relationship for the submillisecond intermediates of protein folding” J. Mol. Biol. : 357,997-1008 (2006) [Abstract]

2005年　

  • Yamaguchi, K., Takahashi, S., Kawai, T., Naiki, H., Goto, Y. “Seeding-dependent propagation and maturation of amyloid fibril conformation” J. Mol. Biol. : 352, 952-960 (2005) [Abstract]
  • Shintaku, M., Matsuura, K., Yoshioka, S., Takahashi, S., Ishimori, K., Morishima, I. “Absence of a detectable intermediate in the compound I formation of horseradish peroxidase at ambient temperature” J. Biol. Chem. :280, 40934-40938 (2005) [Abstract]
  • Kameda, A., Hoshino, M., Higurashi, T., Takahashi, S., Naiki, H., Goto, Y.
    “Nuclear magnetic resonance characterization of the refolding intermediate of beta2-microglobulin trapped by non-native prolyl peptide bond” J. Mol. Biol. : 348, 383-397 (2005) [Abstract]
  • Kimura, T., Akiyama, S., Uzawa, T., Ishimori, K., Morishima, I., Fujisawa, T., Takahashi, S.
    “Specifically collapsed intermediate in the early stage of the folding of ribonuclease A”
    J. Mol. Biol. : 350, 349-362 (2005) [Abstract]
  • Wadai, H., Yamaguchi, K., Takahashi, S., Kanno, T., Kawai, T., Naiki, H., Goto Y.
    “Stereospecific amyloid-like fibril formation by a peptide fragment of beta2-microglobulin.”
    Biochemistry : 44, 157-164 (2005) [Abstract]
  • Kimura, T., Uzawa, T., Ishimori, K., Morishima, I., Takahashi, S., Konno, T., Akiyama, S., Fujisawa, T. “Specific collapse followed by slow hydrogen-bond formation of beta-sheet in the folding of single-chain monellin.” Proc. Natl. Acad. Sci. USA. 102, 2748-2753 (2005) [Abstract]

2004年　

  • Uzawa, T., Akiyama, S., Kimura, T., Takahashi, S.*, Ishimori, K., Morishima, I., Fujisawa, T.*
    “Collapse and search dynamics of apomyoglobin folding revealed by submillisecond observations of alpha-helical content and compactness.” Proc. Natl. Acad. Sci. USA. 101, 1171-1176 (2004) [Abstract]
  • Inuzuka, T., Yun, B. G., Ishikawa, H., Takahashi, S., Hori, H., Matts, R. L., Ishimori, K., Morishima, I. “Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.” J. Biol. Chem. 279, 6778-6682 (2004) [Abstract]
  • Matsuura, K., Yoshioka, S., Takahashi S, Ishimori K, Mogi T, Hori H, Morishima I.
    “Dioxygen reduction by bo-type quinol oxidase from Escherichia coli studied by submillisecond-resolved freeze-quench EPR spectroscopy.” Biochemistry43, 2288-2296 (2004) [Abstract]
  • Matsuura, K., Tosha, T., Yoshioka, S., Takahashi, S., Ishimori, K., Morishima, I.
    “Structuraland functional characterization of “laboratory evolved” cytochrome P450cam mutants showing enhanced naphthalene oxygenation activity.” Biochem. Biophys. Res. Commun. 323, 1209-1215 (2004) [Abstract]
  • Ishikawa, H., Takahashi, S., Ishimori, K., Morishima, I. “Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin.” Biochem. Biophys. Res. Commun. 324, 1095-1100 (2004) [Abstract]
  • Kumita, H., Matsuura, K., Hino, T., Takahashi, S., Hori, H., Fukumori, Y., Morishima, I., Shiro, Y.
    “NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle.”
    J. Biol. Chem. : 279,55247-55254 (2004) [Abstract]
  • Ban, T., Hoshino, M., Takahashi, S., Hamada, D., Hasegawa, K., Naiki, H., Goto, Y. “Direct observation of Abeta amyloid fibril growth and inhibition.” J. Mol. Biol. : 344, 757-767 (2004) [Abstract]
  • Egawa, T., Hishiki, T., Ichikawa, Y., Kanamori, Y., Shimada, H.,Takahashi, S., Kitagawa, T., Ishimura, Y. “Refolding processes of cytochrome P450cam from ferric and ferrous acid forms to the native conformation. Formations of folding intermediates with non-native heme coordination state.” J. Biol. Chem. : 279, 32008-32017 (2004) [Abstract]

2003年　

  • Tosha, T., Yoshioka, S., Takahashi, S., Ishimori, K., Shimada, H., Morishima, I. “NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes.”
    J. Biol. Chem. 278, 39809-39821 (2003) [Abstract]
  • Egawa, T., Yoshioka, S., Takahashi, S., Hori, H., Nagano, S., Shimada, H., Ishimori, K., Morishima, I., Suematsu, M., Ishimura, Y. “Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.” J. Biol. Chem. 278, 41597-41606 (2003) [Abstract]
  • Tanaka, M., Matsuura, K., Yoshioka, S., Takahashi, S., Ishimori, K., Hori, H., Morishima, I.
    “Activationof Hydrogen Peroxide in Horseradish Peroxidase Occurs within ~300μs Observed by a New Freeze-Quench Device” Biophys. J. (2003). 84, 1998-2004. [Abstract]

2002年　

  • Akiyama, S., Takahashi, S., Kimura, T., Ishimori, K., Morishima, I., Nishikawa, Y.,Fujisama, T.,
    “Conformational Landscape of Cytochrome c Folding Studied by Microsecond-Resolved Small Angle X-ray Scattering” Proc. Natl. Acad. Sci. U. S. A.. 99. 1329-1334 (2002) [Abstract]
  • Kimura, T., Takahashi, S., Akiyama, S., Uzawa, T., Ishimori, K., Morishima, I. “Direct Observation of the Multi-step Helix Formation of Poly-L-glutamic acids” J. Am. Chem. Soc. (2002). 124, 11596-11597. [Abstract]
  • Yoshioka, S., Tosha, T., Takahashi, S., Ishimori, K., Morishima, I. “Roles of the Proximal Hydrogen Bonding Network in Cytochrome P450cam-Catalyzed Oxygenation”
    J. Am. Chem. Soc. 124, 14571-14579 (2002) [Abstract]
  • Ishikawa, H., Yun, B.-G., Takahashi, S., Hori, H., Matts, R. L., Ishimori, K., Morishima, I. “NO-induced Activation Mechanism of the Heme-regulated eIF2 Kinase” J. Am. Chem. Soc. 124, 13696-13697 (2002) [Abstract]
  • Tosha, T., Yoshioka, S., Takahashi, S., Hori, H., Ishimori, K., Morishima, I. “Molecular Mechanism of Electron Transfer Reaction in Cytochrome P450cam-Putidaredoxin: Roles of Gln360 at the Heme Proximal Site” Biochemistry 41, 13883-13893 (2002) [Abstract]

2001年　

  • Ishikawa, H., Uchida, T., Takahashi, S., Ishimori, K., Morishima, I. “Ligand Migration in Human Myoglobin: Steric Effects of Isoleucine 107(G8) on O2 and CO Binding” Biophys. J. 80, 1507-1517 (2001) [Abstract]
  • Shibata, Y., Ishikawa, H., Takahashi, S., Morishima, I. “Time-Resolved Hole-Burning Study on Myoglobin: Fluctuation of Restricted Water within Distal Pocket” Biophys. J. 80, 1013-1023 (2001) [Abstract]
  • Yamamoto, K., Ishikawa, H., Takahashi, S., Ishimori, K., Morishima, I., Nakajima, H., Aono, S. “Binding of CO at the Pro2 Side Is Crucial for the Activation of CO-Sensing Transcriptional Activator CooA – H1-NMR Spectroscopic Studies” J. Biol. Chem. 276, 11473-11476 (2001) [Abstract]
  • Yoshioka, S., Takahashi, S., Hori, H., Ishimori, K., Morishima, I. “Proximal Cysteine Residue Is Essential for the Enzymatic Activities of Cytochrome P450cam”
    Eur. J. Biochem. 268, 252-259 (2001) [Abstract]

2000年　

  • Akiyama, S., Takahashi, S.,Ishimori, K., Morishima, I. “Stepwise Formation of Alpha-Helices During Cytochrome c Folding” Nat. Struct. Biol. 7, 514-520 (2000) [Abstract]
  • Ihara, M., Shintaku, M., Takahashi, S., Ishimori, K., Morishima, I. “Conversion of an Electron-Transfer Protein into an Oxygen Binding Protein: The Axial Cytochrome b5 Mutant with an Unusually High O2 Affinity” J. Am. Chem. Soc. 122, 11535-11536 (2000) [Abstract]
  • Ihara, M., Takahashi, S., Ishimori, K., Morishima, I. “Functions of Fluctuation in the Heme-Binding Loops of Cytochrome b5 Revealed in the Process of Heme Incorporation” Biochemistry 39, 5961-5970 (2000) [Abstract]
  • Yoshioka, S., Takahashi, S., Ishimori, K., Morishima, I. “Roles of the Axial Push Effect in Cytochrome P450cam Studied with the Site-Directed Mutagenesis at the Heme Proximal Site” J. Inorg. Biochem. 81, 141-151 (2000) [Abstract]
  • Han, S., Takahashi, S., Rousseau, D. L. “Time Dependence of the Catalytic Intermediates in Cytochrome c Oxidase” J. Biol. Chem. 275, 1910-1919 (2000) [Abstract]