pub_mizukami

水上・発表論文（2015年以前）

［原著論文］

  1. Zhanghua Zeng, Shin Mizukami, Katsumasa Fujita, Kazuya Kikuchi
    An Enzyme-Responsive Metal-Enhanced Near-Infrared Fluorescence Sensor Based on Functionalized Gold Nanoparticles
    Chem. Sci. 2015, 6, 4934–4939.
  2. Kentaro Mochizuki, Lanting Shi, Shin Mizukami, Masahito Yamanaka, Mamoru Tanabe, Wei-Tao Gong, Almar F Palonpon, Shogo Kawano, Satoshi Kawata, Kazuya Kikuchi, Katsumasa Fujita
    Nonlinear Fluorescence Imaging by Using Phtoinduced Charge Separation
    Jpn. J. Appl. Phys.     2015, 54, 042403.
  3. Tatsuya Nakamura, Fuminori Sugihara, Hisashi Matsushita, Yoshichika Yoshioka, Shin Mizukami, Kazuya Kikuchi
    Mesoporous Silica Nanoparticles for 19F Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery
    Chem. Sci.     2015, 6, 1986–1990.
  4. Tatsuya Nakamura, Hisashi Matsushita, Fuminori Sugihara, Yoshichika Yoshioka, Shin Mizukami, Kazuya Kikuchi
    Activatable 19F MRI Nanoparticle Probes for the Detection of Reducing Environments
    Angew. Chem. Int. Ed. 2015, 54, 1007–1010.
  5. Yosuke Funato, Daisuke Yamazaki, Shin Mizukami, Lisa Du, Kazuya Kikuchi, Hiroaki Miki
    Membrane Protein CNNM4-Dependent Mg2+ Efflux Suppresses Tumor Progression
    J. Clin. Invest.     2014, 124, 5398–5410.
  6. Satoshi Okada, Shin Mizukami, Takao Sakata, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi
    Ratiometric MRI Sensors Based on Core-Shell Nanoparticles for Quantitative pH Imaging
    Adv. Mater. 2014, 26, 2989–2992.
  7. Hisashi Matsushita, Shin Mizukami, Fuminori Sugihara, Yosuke Nakanishi, Yoshichika Yoshioka, Kazuya Kikuchi
    Multifunctional Core-shell Silica Nanoparticles for Highly Sensitive 19F Magnetic Resonance Imaging
    Angew. Chem. Int. Ed. 2014, 53, 1008–1011.
  8. Akimasa Yoshimura, Shin Mizukami, Yuki Mori, Yoshichika Yoshioka, Kazuya Kikuchi
    1H MRI Detection of Gene Expression in Living Cells by Using Protein Tag and Biotinylation Probe
    Chem. Lett. 2014, 43, 219–221.
  9. Daisuke Yamazaki, Yosuke Funato, Jiro Miura, Sunao Sato, Satoru Toyosawa, Kazuharu Furutani, Yoshihisa Kurachi, Yoshihiro Omori, Takahisa Furukawa, Tetsuya Tsuda, Susumu Kuwabata, Shin Mizukami, Kazuya Kikuchi, Hiroaki Miki
    Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model
    PLOS Genet. 2013, 9, e1003983.
  10. Eric Lindberg, Shin Mizukami, Keiji Ibata, Takashi Fukano, Atsushi Miyawaki, Kazuya Kikuchi
    Development of Cell-Impermeable Coelenterazine Derivatives
    Chem. Sci. 2013, 4, 4395–4400.
  11. Eric Lindberg, Shin Mizukami, Keiji Ibata, Atsushi Miyawaki, Kazuya Kikuchi
    Development of Luminescent Coelenterazine Derivatives Activatable by β-Galactosidase for Monitoring Dual Gene Expression
    Chem. Eur. J. 2013, 19, 14970–14976.
  12. Tatsuya Nakamura, Shin Mizukami, Miho Tanaka, Kazuya Kikuchi
    Efficient Development of Luminescent Lanthanide(III) Complexes by Solid-Phase Synthesis and On-Resin Screening
    Chem. Asian J. 2013, 8, 2685–2690.
  13. Satoshi Okada, Shin Mizukami, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi
    Nanospherical Polymer as an MRI Sensor without Paramagnetic or Superparamagnetic Species
    Dalton Trans. 2013, 42, 15864–15867.
  14.  Junichi Kikuta, Yoh Wada, Toshiyuki Kowada, Ge-Hong Sun-Wada, Issei Nishiyama, Shin Mizukami, Nobuhiko Maiya, Hisataka, Yasuda, Atsushi Kumanogoh, Kazuya Kikuchi, Ronald Germain, Masaru Ishii
    Dynamic Visualization of RANKL and Th17-Mediated Control of Osteoclast Function
    J. Clin. Invest. 2013, 123, 866–873.
  15. Kalyan K. Sadhu, Shin Mizukami, Kazuya Kikuchi
    pH Induced Dual “OFF-ON-OFF” Switch: Influence of Suitably Placed Carboxylic Acid
    Org. Biomol. Chem. 2013, 11, 563–568.
  16. Zhanghua Zeng, Shin Mizukami, Kazuya Kikuchi
    Simple and Real-Time Colorimetric Assay for Glycosidases Activity Using Functionalized Gold Nanoparticles and its Application for Inhibitor Screening
    Anal. Chem. 2012, 84, 9089–9095.
  17. Reisuke Baba, Yuichiro Hori, Shin Mizukami, Kazuya Kikuchi
    Development of a Fluorogenic Probe with a Transesterification Switch for Detection of Histone Deacetylase Activity
    J. Am. Chem. Soc. 2012, 134, 14310–14313.
  18. Hisashi Matsushita, Shin Mizukami, Yuki Mori, Fuminori Sugihara, Masahiro Shirakawa, Yoshichika Yoshioka, Kazuya Kikuchi
    19F MRI Monitoring of Gene Expression in Living Cells via Cell Surface β-Lactamase Activity
    ChemBioChem 2012, 13, 1579–1583.
  19. Yuichiro Hori, Kyohei Nakaki, Motoki Sato, Shin Mizukami, Kazuya Kikuchi
    Development of Protein Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association and No-Wash Live-Cell Imaging
    Angew. Chem. Int. Ed. 2012, 51, 5611–5614.
  20. Shin Mizukami, Shuji Watanabe, Yuri Akimoto, Kazuya Kikuchi
    No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis
    J. Am. Chem. Soc. 2012, 134, 1623–1629.
  21. Satoshi Okada, Shin Mizukami, Kazuya Kikuchi
    Switchable MRI Contrast Agents Based on Morphological Changes of pH-Responsive Polymers
    Bioorg. Med. Chem. 2012, 20, 769–774.
  22. Kalyan K. Sadhu, Shin Mizukami, Carolyn R. Lanam, Kazuya Kikuchi
    A New Approach for Fluorogenic Protein Labeling via Photoinduced Electron Transfer Based BL-Tag Protein Labeling Method
    Chem. Asian J., 2012, 7, 272–276.
  23. Toshiyuki Kowada, Junichi Kikuta, Atsuko Kubo, Masaru Ishii, Hiroki Maeda, Shin Mizukami, Kazuya Kikuchi
    In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts
    J. Am. Chem. Soc. 2011, 133, 17772–17776.
  24. Shin Mizukami, Taku Yamamoto, Akimasa Yoshimura, Shuji Watanabe, Kazuya Kikuchi
    Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-Based Multicolor Bioimaging
    Angew. Chem. Int. Ed. 2011, 50, 8750–8752.
  25. Shuji Watanabe, Shin Mizukami, Yuri Akimoto, Yuichiro Hori, Kazuya Kikuchi
    Intracellular Protein Labeling with Prodrug-Like Probes Using a Mutant β-Lactamase Tag
    Chem. Eur. J. 2011, 17, 8342–8349.
  26. Shin Mizukami, Hisashi Matsushita, Rika Takikawa, Fuminori Sugihara, Masahiro Shirakawa, Kazuya Kikuchi
    19F MRI Detection of β-Galactosidase Activity for Imaging of Gene Expression
    Chem. Sci. 2011, 2, 1151–1155.
  27. Kalyan K. Sadhu, Shin Mizukami, Shuji Watanabe, Kazuya Kikuchi
    Sequential Ordering among Multicolor Fluorophores for Protein Labeling Facility via Aggregation-Elimination Based β-Lactam Probes
    Mol. BioSyst. 2011, 7, 1766–1772.
  28. Akimasa Yoshimura, Shin Mizukami, Yuichiro Hori, Shuji Watanabe, Kazuya Kikuchi
    Cell-Surface Protein Labeling with Luminescent Nanoparticles through Biotinylation by Using Mutant β-Lactamase-Tag Technology
    ChemBioChem 2011, 12, 1031–1034.
  29. Shuji Watanabe, Shin Mizukami, Yuichiro Hori, and Kazuya Kikuchi
    Multicolor Protein Labeling in Living Cells Using Mutant β-Lactamase-Tag Technology
    Bioconjug. Chem. 2010, 21, 2320–2326.
  30. Kalyan K. Sadhu, Shin Mizukami, Shuji Watanabe, Kazuya Kikuchi
    Turn-on Fluorescent Switch Involving Aggregation and Elimination Processes for β-Lactamase-Tag
    Chem. Commun. 2010, 46, 7403–7405.
  31. Shin Mizukami, Mariko Hosoda, Takafumi Satake, Satoshi Okada, Yuichiro Hori, Toshiaki Furuta, Kazuya Kikuchi
    Photocontrolled Compound Release System Using Caged Antimicrobial Peptide
    J. Am. Chem. Soc. 2010, 132, 9524–9525.
  32. Satoshi Okada, Shin Mizukami, Kazuya Kikuchi
    Application of a Stimuli-responsive Polymer to the Development of Novel MRI Probes
    ChemBioChem 2010, 11, 785–787.
  33. Yuichiro Hori, Hideki Ueno, Shin Mizukami, Kazuya Kikuchi
    Photoactive Yellow Protein-based Protein Labeling System with Turn-on Fluorescence Intensity
    J. Am. Chem. Soc. 2009, 131, 16610–16611.
  34. Shin Mizukami, Satoshi Okada, Satoshi Kimura, Kazuya Kikuchi
    Design and Synthesis of Coumarin-based Zn2+ Probes for Ratiometric Fluorescence Imaging
    Inorg. Chem. 2009, 48, 7630–7638.
  35. Kazuya Kikuchi, Shigeki Hashimoto, Shin Mizukami, Tetsuo Nagano
    Anion Sensor-Based Ratiometric Peptide Probe for Protein Kinase Activity
    Org. Lett. 2009, 11, 2732–2735.
  36. Shin Mizukami, Shuji Watanabe, Kazuya Kikuchi
    Development of Ratiometric Fluorescent Probes for Phosphatases by Using a pKa-Switching Mechanism
    ChemBioChem 2009, 10, 1465−1468.
  37. Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Masahiro Shirakawa, Kazuya Kikuchi
    Dual-Function Probe to Detect Protease Activity for Fluorescence Measurement and 19F MRI
    Angew. Chem. Int. Ed. 2009, 48, 3641–3643.
  38. Shin Mizukami, Shuji Watanabe, Yuichiro Hori, Kazuya Kikuchi
    Covalent Protein Labeling Based on Noncatalytic β-Lactamase and a Designed FRET Substrate
    J. Am. Chem. Soc. 2009, 131, 5016–5017.
  39. Shin Mizukami, Kazuhiro Tonai, Masahiro Kaneko, Kazuya Kikuchi
    Lanthanide-Based Protease Activity Sensors for Time-Resolved Fluorescence Measurements
    J. Am. Chem. Soc. 2008, 130, 14376–14377.
  40. Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Yuichiro Hori, Hidehito Tochio, Markus Wälchli, Masahiro Shirakawa, Kazuya Kikuchi
    Paramagnetic Relaxation-Based 19F MRI Probe to Detect Protease Activity
    J. Am. Chem. Soc. 2008, 130, 794–795.
  41. Shin Mizukami, Tae Woo Kim, Sandra A. Helquist, Eric T. Kool
    Varying DNA Base Pair Size in Sub-Angstrom Increments: Evidence for a Loose, Not Large, Active Site in Low-fidelity Dpo4 Polymerase
    Biochemistry 2006, 45, 2772–2778.
  42. Shin Mizukami, Hirohiko Houjou, Kenta Sugaya, Hideo Tokuhisa, Emiko Koyama, Takeshi Sasaki, Masatoshi Kanesato
    Fluorescence Color Modulation by Intramolecular and Intermolecular π-π Interactions in a Helical Zinc(II) Complex
    Chem. Mater. 2005, 17, 50–56.
  43. Shin Mizukami, Hirohiko Houjou, Yoshinobu Nagawa, Masatoshi Kanesato
    First Helical Zinc(II) Complex with a Salen Ligand
    Chem. Commun. 2003, 1148–1149.
  44. Shin Mizukami, Hirohiko Houjou, Masatoshi Kanesato, Kazuhisa Hiratani
    Adjustment of Twist Angles in Pseudo-helical Lanthanide Complexes by the Size of Metal Ions
    Chem. Eur. J. 2003, 9, 1521–1528.
  45. Shin Mizukami, Tetsuo Nagano, Yasuteru Urano, Akira Odani, Kazuya Kikuchi
    A Fluorescent Anion Sensor That Works in Neutral Aqueous Solution for Bioanalytical Application
    J. Am. Chem. Soc. 2002, 124, 3920–3925.
  46. Yasutomo Kawanishi, Kazuya Kikuchi, Hideo Takakusa, Shin Mizukami, Yasuteru Urano, Tsunehiko Higuchi, Tetsuo Nagano
    Design and Synthesis of Intramolecular Resonance Energy Transfer Probes for Use in Aqueous Solution
    Angew. Chem. Int. Ed. 2000, 39, 3438–3440.
  47. Mitsunori Koresawa, Kazuya Kikuchi, Shin Mizukami, Hirotatsu Kojima, Yasuteru Urano, Tsunehiko Higuchi, Tetsuo Nagano
    Development Time-Resolved Fluorometric Detection System Using Diffusion-Enhanced Energy Transfer
    Anal. Chem. 2000, 72, 4904–4907.
  48. Shin Mizukami, Kazuya Kikuchi, Tsunehiko Higuchi, Yasuteru Urano, Tetsuo Mashima, Takashi Tsuruo, Tetsuo Nagano
    Imaging of Caspase-3 Activation in HeLa Cells Stimulated with Etoposide Using a Novel Fluorescent Probe
    FEBS Lett. 1999, 453, 356–360.

 

【著書総説】

（英文）

  1. Shin Mizukami, Yuichiro Hori, Kazuya Kikuchi
    Small-Molecule Based Protein-Labeling Technology in Live Cell Studies: Probe-Design Concepts and Applications
    Acc. Chem. Res. 2014, 47, 247–256.
  2. Kalyan K. Sadhu, Shin Mizukami, Kazuya Kikuchi
    Zinc: Fluorescent Sensors as Molecular Probes of It
    Encyclopedia of Metalloproteins (Springer, 2013)
  3. Shin Mizukami
    Development of Molecular Imaging Tools to Investigate Protein Functions by Chemical Probe Design
    Chem. Pharm. Bull. 2011, 59, 1435–1446.4.       Kalyan K. Sadhu, Shin Mizukami, Yuichiro Hori, Kazuya Kikuchi
    Switching Modulation for Protein Labeling with Activatable Fluorescent Probe
    ChemBioChem 2011, 12, 1299–1308.

（和文）

  1. 水上進
    酵素変異体に基づく蛋白質ラベル化技術の開発と新たな生物学研究ツールへの展開
    生化学 2014, 86, 154–159.
  2. 水上進・菊地和也
    細胞蛋白質への機能性分子ラベリング技術
    未来材料 2013, 2, 5–10.
  3. 水上進
    ナノ粒子設計に基づく機能性1H MRIプローブの開発
    薬学雑誌 2013, 133, 351–354.
  4. 水上進・菊地和也
    生体反応を可視化する19F MRIプローブ開発
    生物物理 2012, 52, 24–25.
  5. 水上進
    論文に見る最重要概念と革新実験データ　「In vivo visualization of gene expression using magnetic resonance imaging」
    ここまで進んだバイオセンシング・イメージング　日本化学会編（化学同人，2012年）
    第4章, pp. 28–31.
  6. 水上進・渡辺修司・吉村彰真・菊地和也
    β-ラクタマーゼを用いた蛋白質可視化技術の開発
    JSMI Report 2011, 4, 19–21.
  7. 水上進・菊地和也
    機能性分子設計に基づく蛋白質の蛍光ラベル化
    蛍光イメージング／MRIプローブの開発（シーエムシー出版，2011年）
    第9章, pp. 79–88.
  8. 水上進・菊地和也
    酵素活性を検出する19F MRIプローブの開発
    蛍光イメージング／MRIプローブの開発（シーエムシー出版，2011年）
    第11章, pp. 97–103.
  9. 水上進・菊地和也
    化学プローブのデザイン・合成によるタンパク質機能の可視化ツール
    生化学 2010, 82, 21–29.
  10. 水上進・松下尚嗣・菊地和也
    金属イオンプローブを用いた生体機能イメージング
    化学フロンティア―生命現象を理解する分子ツール（化学同人，2010年）, pp.15–24.
  11. 菊地和也・水上進
    in vivoイメージングを目指した可視化プローブ開発
    ぶんせき 2009, 4, 200–202.
  12. 水上進
    Measurement of Cytosolic Free Ca2+ in Individual Small Cells Using Fluorescence Microscopy with Dual Excitation Wavelengths
    蛋白質核酸酵素　増刊号　ケミカルバイオロジー 2007, 52, 1760–1761.
  13. 長野哲雄・鈴木紀行・平野智也・水上進・瀬月内健一・高草英生
    蛍光測定－各パラメーターの測定法と応用研究
    生体機能関連化学実験法（日本化学会生体機能関連化学部会編，2003年）
    第7章， 113–125.