東北大学多元物質科学研究所
細胞機能分子化学研究分野 水上研究室

2019

• Improvement in Photostability of Fluorescein by Lanthanide Ions based on Energy Transfer-Based Triplet State Quenching^NEW
  T. Imoto, M. Muramatsu, H. Miyasaka, S. Mizukami, K. Kikuchi
  Chem. Lett., (2019) in press.

• Biophysical characterization of heme binding to the intrinsically disordered region of Bach1^NEW
  K. Segawa, M. Watanabe-Matsui, K. Tsuda, T. Matsui, M. Shirouzu, K. Igarashi, K. Murayama
  Eur. Biophys. J., (2019) 48, 361-369.

• Functional Heme Binding to the Intrinsically Disordered C-Terminal Region of Bach1, a Transcriptional Repressor^NEW
  K. Segawa, M. Watanabe-Matsui, T. Matsui, K. Igarashi, K. Murayama
  Tohoku J. Exp. Med., (2019) 247, 153-159.

• Light-wavelength-based Quantitative Control of Dihydrofolate Reductase Activity Using Photochromic Isostere of Inhibitor^NEW
  T. Mashita, T. Kowada, H. Takahashi, T. Matsui, S. Mizukami
  ChemBioChem, (2019) 20, 1382-1386

2018

• Perfluorocarbon-based ¹⁹F MRI Nanoprobes for In Vivo Multicolor Imaging^NEW
  K. Akazawa, F. Sugihara, T. Nakamura, H. Matsushita, H. Mukai, R. Akimoto, M. Minoshima, S. Mizukami, K. Kikuchi
  Angew. Chem., Int. Ed., (2018) 57, 16742-16747

• Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase
  T. Matsui, R. Sugiyama, K. Sakanashi, Y. Tamura, M. Iida, Y. Nambu, T. Higuchi, M. Suematsu, M. Ikeda-Saito
  J. Biol. Chem., (2018) 293, 16931-16939.
  

• MRIなどへの機能性含フッ素プローブ応用^NEW
  水上進
  有機フッ素化合物の最新動向（シーエムシー出版）, 第2章3節, pp.151–160 (2018). 

• Sensing Caspase-1 Activity Using Activatable ¹⁹F MRI Nanoprobes with Improved Turn-on Kinetics
  K. Akazawa, F. Sugihara, M. Minoshima, S. Mizukami, K. Kikuchi
  Chem. Commun., (2018) 54, 11785-11788 

• Highly Sensitive Detection of Caspase-3/7 Activity in Living Mice Using Enzyme-Responsive ¹⁹F MRI Nanoprobes
  K. Akazawa, F. Sugihara, T. Nakamura, S. Mizukami, K. Kikuchi
  Bioconjugate Chem., (2018) 29, 1720–1728. 

• Ratiometric Imaging of Intracellular Mg²⁺ Dynamics Using a Red Fluorescent Turn-off Probe and a Green Fluorescent Turn-on Probe
  Y. Matsui, S. Mizukami, K. Kikuchi
  Chem. Lett., (2018) 47, 23–26. 

2017

• Intracellular protein-labeling probes for multicolor single-molecule imaging of immune receptor-adaptor molecular dynamics
  R. Sato, J. Kozuka, M. Ueda, R. Mishima, Y. Kumagai, A. Yoshimura, M. Minoshima, S. Mizukami, K. Kikuchi
  J. Am. Chem. Soc., (2017) 139, 17397–17404. 

• Visualization of Long-term Mg²⁺ Dynamics in Apoptotic Cells with a Novel Targetable Fluorescent Probe
  Y. Matsui, Y. Funato, H. Imamura, H. Miki, S. Mizukami, K. Kikuchi
  Chem. Sci., (2017) 8, 8255-8264. 

• Highly selective tridentate fluorescent probes for visualizing intracellular Mg²⁺ dynamics without interference from Ca²⁺ fluctuation
  Y. Matsui, K. K. Sadhu, S. Mizukami, K. Kikuchi
  Chem. Commun., (2017) 53, 10644-10647 

• Enzyme-Triggered Compound Release using Functionalized Antimicrobial Peptide Derivatives
  S. Mizukami, M. Kashibe, K. Matsmoto, Y. Hori, K. Kikuchi
  Chem. Sci., (2017) 8, 3047-3053 

• Targetable Fluorescent Sensors for Advanced Cell Function Analysis
  S. Mizukami
  J. Photochem. Photobiol. C (2017) 30, 24-35 

• Reaction intermediates in the heme degradation reaction by HutZ from Vibrio cholera 
  T. Uchida, S. Sekine, N. Dojun, A. Lewis-Ballester, I. Ishigami, T. Matsui, S. Yeh, K. Ishimori
  Dalton Trans., (2017) 46, 8104-8109

2016

• Real-time Intravital Imaging of pH Variation Associated with Osteoclast Activity
  H. Maeda, T. Kowada, J. Kikuta, M. Furuya, M. Shirazaki, S. Mizukami, M. Ishii, K. Kikuchi
  Nat. Chem. Biol., (2016) 12, 579-585 [ISI] [プレスリリース]

• Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation
  T. Matsui, S. Nambu, C. W. Goulding, S. Takahashi, H. Fujii, M. Ikeda-Saito
  Proc. Natl. Acad. Sci. (2016) 113, 3779-84 [ISI] [プレスリリース]

• Artificial Hydrogenases based on Cobaloximes and Heme Oxygenase
  M. Bacchi, E. Veinberg, M. J. Field, J. Niklas, T. Matsui, D. M Tiede, O. G. Poluektov, M. Ikeda-Saito, M. Fontecave V. Artero
  ChemPlusChem (2016) 81, 1083-1089

• Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding
  T. Suenaga, M. Watanabe-Matsui, H. Shima, T. Matsui, M. Ikeda-Saito, K. Igarashi, K. Murayama
  J. Biochem. (2016) 160, 291-298.
  

2015年以前

　・水上　教授

　・松井　准教授

　・小和田　助教