{"id":95,"date":"2015-04-13T16:48:35","date_gmt":"2015-04-13T07:48:35","guid":{"rendered":"https:\/\/www2.tagen.tohoku.ac.jp\/lab\/wada\/?p=95"},"modified":"2015-12-24T16:49:05","modified_gmt":"2015-12-24T07:49:05","slug":"%e3%80%904-15-15%e6%99%82%e3%80%912015%e5%a4%9a%e5%85%83%e7%a0%94%e7%94%9f%e5%91%bd%e6%9c%89%e6%a9%9f%e3%83%bb%e7%89%a9%e7%90%86%e5%8c%96%e5%ad%a6%e3%82%bb%e3%83%9f%e3%83%8a%e3%83%bc01%e3%83%9a","status":"publish","type":"post","link":"https:\/\/www2.tagen.tohoku.ac.jp\/lab\/wada\/news\/95\/","title":{"rendered":"\u30104.15.15\u6642\u30112015\u591a\u5143\u7814\u751f\u547d\u6709\u6a5f\u30fb\u7269\u7406\u5316\u5b66\u30bb\u30df\u30ca\u30fc01\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66Takashi YONETANI\u6559\u6388\u8b1b\u6f14\u4f1a"},"content":{"rendered":"

4\u670815\u65e5\u6c34\u66dc1\uff15\u6642\u3088\u308a\u30a2\u30e1\u30ea\u30ab\u30fb\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66\u3000Takashi YONETANI\u6559\u6388\u306b\u3088\u308b\u591a\u5143\u7814\u751f\u547d\u6709\u6a5f\u30fb\u7269\u7406\u5316\u5b66\u30bb\u30df\u30ca\u30fc\uff101\u3092 \u5b9f\u65bd\u81f4\u3057\u307e\u3059\u3002\u7686\u69d8\u3001\u3054\u591a\u5fd9\u306a\u3053\u3068\u3068\u306f\u5b58\u3058\u307e\u3059\u304c\u3001\u662f\u975e\u591a\u6570\u306e\u3054\u53c2\u52a0\u3092\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n

\u65e5\u3000\u6642\uff1a\u30004\u670815\u65e5(\u6c34\u66dc\u65e5)\u3000 \u5348\u5f8c3\u6642\u20144\u6642\u534a\u9803<\/p>\n

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\u4e3b\u3000\u50ac\uff1a\u3000\u6771\u5317\u5927\u591a\u5143\u7814\u30fb\u7269\u8cea\u30c7\u30d0\u30a4\u30b9\u9818\u57df\u5171\u540c\u7814\u7a76\u62e0\u70b9\u30fb\u30ca\u30ce\u30de\u30af\u30ed\u7269\u8cea\u30fb\u30c7\u30d0\u30a4\u30b9\u30fb\u30b7\u30b9\u30c6\u30e0 \u5275\u88fd\u30a2\u30e9\u30a4\u30a2\u30f3\u30b9<\/p>\n

\u8b1b\u3000\u5e2b\uff1a\u3000Perelman School of Medicine, Biochem. & Biophys., Univ. of Pennsylvania, Philadelphia, USA\u3000Prof. Takashi YONETANI<\/p>\n

\u6f14\u3000\u984c\uff1a\u3000\u3000The O2-Affinity and Cooperativity of Hemoglobin are regulated by the Effector-Linked 4D-Structural Changes (Protein Dynamics) rather than the Ligand-Linked 3D-Structural Changes<\/p>\n

\u6982\u3000\u3000\u8981\uff1a\u3000\u3000The current, widely-held mechanism of allostery of hemoglobin (Hb) has been that the changes from the R-quaternary\/tertiary structures of oxy-Hb to the T-quaternary\/tertiary structures of deoxy-Hb exert certain structural constraints on the coordination structure of the heme group, leading to a lower O2-affinity of the hemes and thus that of Hb [1].\u00a0However, we found that there is no causal correlation between the static T\/R-quaternary structures and the low\/ high O2-affinities of Hb [2]. \u00a0We explore an alternative mechanism of the regulation of the ligand-affinity and cooperativity in Hb.<\/p>\n

\u4e16\u8a71\u4eba\uff1a\u548c\u7530\u5065\u5f66\uff08E-Mail\uff1ahiko@tagen.tohoku.ac.jp<\/a>\uff1bEX.\u00a0 5608\uff09<\/p>\n

 <\/p>\n

\u30a2\u30e1\u30ea\u30ab\u30fb\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66Takashi YONETANI\u6559\u6388\u306f\u3001\u751f\u4f53\u5185\u3067\u6700\u3082\u91cd\u8981\u306a\u6a5f\u80fd\u306e\u4e00\u3064\u3067\u3042\u308b\u9178\u7d20\u306e\u904b\u642c\u30fb\u6388\u53d7\u306e\u6a5f\u80fd\u3092\u62c5\u3046\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306e\u6a5f\u80fd\u89e3\u660e\u306b\u95a2\u3057\u3001\u6975\u3081\u3066\u512a\u308c\u305f\u4e16\u754c\u6700\u5148\u7aef\u306e\u7814\u7a76\u6210\u679c\u3092\u7d9a\u3005\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4e16\u754c\u30c8\u30c3\u30d7\u7814\u7a76\u8005\u3067\u3059\u3002\u4eca\u56de\u3001\u6765\u65e5\u30fb\u5fa1\u6765\u5b66\u9802\u304f\u6a5f\u4f1a\u3092\u6d3b\u7528\u3057\u3066\u3001\u9178\u7d20\u306b\u5bfe\u3059\u308b\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306e\u89aa\u548c\u6027\u5236\u5fa1\u6a5f\u69cb\u306b\u95a2\u3057\u591a\u5143\u7814\u3067\u30bb\u30df\u30ca\u30fc\u3092\u3057\u3066\u9802\u304f\u4e8b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u5e74\u5ea6\u521d\u3081\u3067\u7686\u69d8 \u304a\u5fd9\u3057\u3044\u3053\u3068\u3068\u306f\u601d\u3044\u307e\u3059\u304c\u3001\u662f\u975e\u591a\u6570\u306e\u596e\u3063\u3066\u306e\u3054\u53c2\u52a0\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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