4\u670828\u65e5\u706b\u66dc1\uff15\u6642\u3088\u308a\u30c9\u30a4\u30c4\u30fbJohannes Gutenberg University Mainz\u3000Axel M\u00fcller\u6559\u6388\u306b\u3088\u308b2015\u591a\u5143\u7814\u751f\u547d\u6709\u6a5f\u30fb\u7269\u7406\u5316\u5b66\u30bb\u30df\u30ca\u30fc02\u3092 \u5b9f\u65bd\u81f4\u3057\u307e\u3059\u3002\u7686\u69d8\u3001\u3054\u591a\u5fd9\u306a\u3053\u3068\u3068\u306f\u5b58\u3058\u307e\u3059\u304c\u3001\u662f\u975e\u591a\u6570\u306e\u3054\u53c2\u52a0\u3092\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n
2015\u5e74\u5ea6\u3000\u7b2c\uff11\u56deAIMR\u30b8\u30e7\u30a4\u30f3\u30c8\u30bb\u30df\u30ca\u30fc\u30fb2015\u6709\u6a5f\u751f\u547d\u30fb\u7269\u7406\u5316\u5b66\u30bb\u30df\u30ca\u30fc02\uff1a<\/p>\n
Prof. Axel M\u00fcller (Institute of Organic Chemistry, Johannes Gutenberg University Mainz)\u8b1b\u6f14\u4f1a<\/p>\n
\u4e3b\u50ac\/ Organizer\uff1a\u00a0\u00a0\u00a0 \u6771\u5317\u5927\u5b66 \u539f\u5b50\u30fb\u5206\u5b50\u6750\u6599\u79d1\u5b66\u9ad8\u7b49\u7814\u7a76\u6a5f\u69cb\uff08AIMR\uff09\u3001\u591a\u5143\u7269\u8cea\u79d1\u5b66\u7814\u7a76\u6240\uff08IMRAM\uff09<\/p>\n
\u5171\u50ac\/Co-organizer\uff1a\u00a0\u00a0\u00a0 \u7269\u8cea\u30c7\u30d0\u30a4\u30b9\u9818\u57df\u5171\u540c\u7814\u7a76\u62e0\u70b9\u3001\u30ca\u30ce\u30de\u30af\u30ed\u7269\u8cea\u30fb\u30c7\u30d0\u30a4\u30b9\u30fb\u30b7\u30b9\u30c6\u30e0\u5275\u88fd\u30a2\u30e9\u30a4\u30a2\u30f3\u30b9\u00a0\u4ed6<\/p>\n
\u65e5\u6642\/ Date\uff1a\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2014\u5e744\u670828\u65e5(\u706b)15\u6642\uff5e16\u664230\u5206\/ from 3pm to 4:30pm on April 28(Tue)<\/p>\n
\u5834\u6240\/ Venue\uff1a\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u7247\u5e73\u5317\u9580\u4f1a\u99282\u968e\u30a8\u30b9\u30d1\u30b9\/\u3000ESPASS, Katahira Kitamon Commons<\/span><\/p>\n \u91d1\u5c5e\u6750\u6599\u7814\u7a76\u62402\u53f7\u99281\u968e\u91d1\u7814\u8b1b\u5802\/\u3000Tohoku Univ. IMR Auditorium<\/p>\n \u984c\u76ee\/ Title\uff1a\u00a0\u00a0\u00a0\u00a0\u00a0 Self-Organized Multicompartment Nanostructures Inspired by the Cell: Basic Findings and Biomedical Applications<\/strong><\/p>\n \u8b1b\u5e2b\/ Speaker\uff1a\u00a0\u00a0\u00a0\u00a0 Prof. Axel M\u00fcller (Institute of Organic Chemistry, Johannes Gutenberg University Mainz)<\/p>\n \u6982\u8981\/ Abstract\uff1a\u00a0\u00a0\u00a0\u00a0 Compartmentalization is the most important feature in living organisms, best seen in plant or animal cells, where different compartments have different functions. We aim at mimicking nature in synthesizing multicompartment micelles, which simultaneously can host different payloads, such as drugs or magnetic or fluorescent nanoparticles. The self-assembly of triblock terpolymers (also known as ABC triblock copolymers) in solution and in the bulk are ideally suited for such a task. A typical example is polystyrene-block<\/em>-polybutadiene-block<\/em>-poly(methyl methacrylate) (SBM). Compartmentalization can occur either in the corona or in the core. We have prepared corona-compartmentalized nanoparticles (Janus spheres, cylinders, or disks) by crosslinking domains in the bulk nanostructures of triblock terpolymers. These Janus micelles have superior properties as interfacial agents, as stabilizers in emulsion polymerization, as compatibilizers of polymer blends, or for the solubilization of carbon nanotubes. Here we present a flexible route for the hierarchical, guided self-assembly of triblock terpolymers into multicompartment micelles (MCMs) of different shapes and sizes, simply by choosing the right solvent conditions and solvent sequences. These MCMs can have spherical shapes, like hamburgers, clovers, or footballs. However, by choosing the right terpolymers composition we can also trigger the shapes in a way that they reversibly form worm-like structures with alternating compartments of, e.g. polystyrene and polybutadiene, with a corona of PMMA. The different compartments can be loaded with various nanoparticles or drugs. Co-assembly of AB- and ABA-style building blocks for MCMs leads to new, complex linear structures at a further level of hierarchy, resembling caterpillars, and allowing control of the chain length from less than 1 \u03bcm up to 30 \u03bcm.A new triblock terpolymer, polybutadiene-block-poly(quaternized 2-vinylpyridene)-block- poly(methacrylic acid) (PVqMAA) forms multicompartment micelles in water with patches of an interpolyelectrolyte complex (IPEC) between the shorter cationic and a part of the longer anionic block. Interaction of the PMAA corona of these micelles with block copolymer of a polycation and poly(ethylene oxide) leads to complex core-shell-shell-corona micelles or even \u201cpaddle-wheel\u201d structures. These structures are used host nanoparticles or drugs.<\/p>\n Axel H. E. M\u00fcller obtained his Ph.D. in 1977 from the Johannes Gutenberg University in Mainz, working with Prof. G. V. Schulz. From 1999-2012 he was full professor and chair of Macromolecular Chemistry at the University of Bayreuth. In October 2012 he retired from Bayreuth and moved back to Mainz University to continue research as a Fellow of the Gutenberg Research College. His research interest focuses on the design of complex polymer and hybrid structures by controlled\/living polymerization techniques and on self-organized nanostructures obtained from these polymers in bulk and solution. Structures of interest include multicompartment micelles, soft Janus particles, cylindrical core-shell brushes, and hybrids of polymers and inorganic or biological materials. He has published over 450 research papers and edited various books. His papers have been cited more than 15,000 times. He is Senior Editor of the journal Polymer<\/em>.<\/strong><\/p>\n <\/p>\n \u554f\u5408<\/strong>\/<\/strong>Contact<\/strong>\uff1a<\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>\u6817\u539f\u548c\u679d\u6559\u6388<\/strong>\uff08<\/strong>WPI-AIMR\/<\/strong>\u591a\u5143\u7814\uff09\uff1a<\/strong>Prof. Kazue KURIHARA (kurihara@tagen.tohoku.ac.jp)<\/strong><\/p>\n \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>\u548c\u7530\u5065\u5f66\u6559\u6388<\/strong>\uff08\u591a\u5143\u7814<\/strong>\/IMRAM<\/strong>\uff09\uff1a<\/strong>Prof. Takehiko WADA<\/strong>\uff08<\/strong>hiko@tagen.tohoku.ac.jp<\/strong>\uff09<\/strong><\/p>\n