小井川浩之

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Hiroyuki OIKAWA

研究テーマ

「マイクロ秒分解一分子FRET測定による蛋白質の構造変化の追跡」

所属学会

  • 日本生物物理学会
  • 日本蛋白質科学会
  • 分子科学会

業績リスト

原著論文

  • Takuhiro Otosu, Kunihiko Ishii, Hiroyuki Oikawa, Munehito Arai, Satoshi Takahashi, and Tahei Tahara, “Highly Heterogeneous nature of the Native and Unfolded States of the B Domain of Protein A Revealed by Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy”, J. Phys. Chem.B,121(22), 5463-5473(2017)
  • Masataka Saito, Supawich Kamonprasertsuk, Satomi Suzuki, Kei Nanatani, Hiroyuki Oikawa, Keiichiro Kushiro, Madoka Takai, Po-Ting Chen, Eric Hsin-Liang Chen, Rita Pei-Yeh Chen, and Satoshi Takahashi, “Significant Heterogeneity and Slow Dynamics of the Unfolded Ubiquitin Detected by Confocal Method of Single-Molecule Fluorescence Spectroscopy” J. Phys. Chem. B (2016) doi10.1021/acs.jpcb.6b05481
  • Hiroyuki Oikawa, Kiyoto Kamagata ,Munehito Arai, and Satoshi Takahashi “Complexity of the Folding Transition of the B domain of Protein A Revealed by the High-Speed Tracking of Single-Molecule Fluorescence Time Series” The Journal of Physical Chemistry B, 119(20), 6081-6091  (2015)
  • Hiroyuki Oikawa, Yuta Suzuki, Masataka Saito, Kiyoto Kamagata, Munehiro Arai and Satoshi Takahashi “Microsecond dynamics of an unfolded protein by a line confocal tracking of single molecule fluorescence” Scientific Reports 3, (2013) Article number:2151, doi:10.1038/srep02151
  • Uchiyama, D., Hoshino, H., Otomo, K., Kato, T., Onda, K., Watanabe, A., Oikawa, H., Fujiyoshi, S., Matsushita, M., Nango, M., Watanabe, N., Sumino, A., and Dewa, T., “Single-protein study of photoresistance of pigment-protein complex in lipid bilayer”,Chem. Phys. Lett., 511, 135-137 (2011)
  • Uchiyama, D., Oikawa, H., Otomo, K., Nango, M., Dewa, T., Fujiyoshi, S., Matsushita, M., “Reconstitution of bacterial photosynthetic unit in a lipid bilayer studied by single-molecule spectroscopy at 5 K”, Phys. Chem. Chem. Phys., 13, 11615-11619 (2011)
  • Hiroyuki Oikawa, Satoru Fujiyoshi, Takehisa Dewa, Mamoru Nango, and Michio Matsushita “How Deep Is the Potential Well Confining a Protein in a Specific Conformation? A Single-Molecule Study on Temperature Dependence of Conformational Change between 5 and 18 K. “ J.Am. Chem. Soc.,(2008)  130, pp 4580-4581. [Abstract]

総説&著書

  • Satoshi Tkahahshi, Kiyoto Kamagata, Hiroyuki Oikawa
    “Where the complex things are: single molecule andensemble spectroscopic investigations of protein folding dynamics”
    Current Opinion in Structural Biology, volume 36, 1-9, 2016 
  • 小井川浩之・齊藤雅嵩・高橋聡
    「マイクロ秒分解一分子蛍光測定で観るタンパク質の構造変化」
    生物物理54 (5), 276-279, 2014
  • 小井川浩之・高橋聡
    「ライン共焦点顕微鏡を用いた高速一分子蛍光観察」
    分光研究, 62巻5号, 232-234, 2013
  • 小井川浩之・鎌形清人・高橋聡
    「揺らぎ・ダイナミクスと生体機能~物理化学的視点から見た生体分子~」4.1, 4.2節
    化学同人(42-55)  2013年9月
  • 小井川浩之・鎌形清人・高橋聡 
    「一分子蛍光観察法を用いたタンパク質フォールディングの解明~Single Molecule Observation on the Folding Process of Proteins~」高分子Vol.60 (2011)