Nango LaboratoryQuantum beam-based structural biology and chemistry,Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

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  • 2021/04/05
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    The homepage of Nango Laboratory has been released.
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Capturing the structural dynamics of a biomolecule at work using a quantum beam

A protein is one of the biomolecules essential to life phenomena, such as cell signaling, in vivo catalytic reactions, storage, and transport. The three-dimensional structure of a protein, which consists of several amino acids, is closely related to its function, and there has been an interest in how a protein structurally changes when it performs its functions. However, it remains challenging to capture reactions or movements in diverse proteins during a wide time scale (femtoseconds to seconds) at an atomic level.

Our laboratory uses a quantum beam such as an X-ray free-electron laser, synchrotron radiation, or an electron beam to visualize actual chemical and structural changes in proteins. For instance, we aim to reveal the switching on/off mechanism of light-sensitive proteins and reaction mechanism of enzymes catalyzing unique reactions. Moreover, we aim to design and create protein molecules with new functions based on precise information from dynamic structural analysis.

Research